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[中国透析患者高钾血症的现状]

[Current status of hyperkalemia in dialysis patients in China].

作者信息

Huang N Y, Liu Y Y, Yu J W, Xu Y W, Zheng X H, Zhang D H, Ai Z, Wu H S, Diao X W, Ye X Q, Yi C Y, Mao H P, Yang X, Yu X Q, Chen W

机构信息

Department of Nephrology, the First Affiliated Hospital of Sun Yat-sen University/Key Laboratory of Nephrology, National Health Commission/Guangdong Provincial Key Laboratory of Nephrology, Guangzhou 510080, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2021 Nov 16;101(42):3466-3471. doi: 10.3760/cma.j.cn112137-20210802-01710.

Abstract

To investigate the prevalence and associated factors of hyperkalemia in dialysis patients. Patients underwent hemodialysis (HD) and peritoneal dialysis (PD) from multi-center databases were recruited from January 2017 to December 2019, and those aged ≥18 years and with dialysis duration ≥3 months were included to analyze the prevalence and related factors of hyperkalemia. A total of 12 364 patients were enrolled in the study, and 6 836 cases were men. The average age of the patients was (51±15) years. Among these patients, 4 230 cases underwent HD while 8 134 received PD. Hyperkalemia was detected in 20.7% (2 554/12 364) of the patients while hypokalemia was found in 17.0%(2 102/12 364) of the patients. Multivariate logistic regression showed that HD (=2.25, 95%: 1.54-3.30), diabetes mellitus (DM) (=1.65, 95%: 1.17-2.32), high body mass index (BMI) (=1.06, 95%: 1.03-1.09), high levels of serum albumin (=1.04, 95%: 1.01-1.07) and phosphorus (=3.12, 95%: 2.44-4.00), low levels of serum bicarbonate (=0.89, 95%: 0.87-0.92), triglycerides (=0.76, 95%: 0.68-0.85) and creatinine (=0.95, 95%: 0.90-0.99), usage of angiotensin converting enzyme inhibitor/Angiotensin Ⅱ receptor antagonist (ACEI/ARB, =1.38, 95%: 1.11-1.72) and beta-blocker (=1.32, 95%: 1.07-1.64) were associated with hyperkalemia. Hyperkalemia occurred in 20.7% of the dialysis patients. HD, DM, high BMI, high levels of serum albumin and phosphorus, low levels of serum bicarbonate, triglycerides and creatinine, use of ACEI/ARB were associated with hyperkalemia.

摘要

为调查透析患者高钾血症的患病率及相关因素。从多中心数据库中招募了2017年1月至2019年12月期间接受血液透析(HD)和腹膜透析(PD)的患者,纳入年龄≥18岁且透析时间≥3个月的患者,以分析高钾血症的患病率及相关因素。共有12364例患者纳入本研究,其中男性6836例。患者的平均年龄为(51±15)岁。这些患者中,4230例接受HD,8134例接受PD。20.7%(2554/12364)的患者检测到高钾血症,17.0%(2102/12364)的患者发现低钾血症。多因素logistic回归显示,HD(=2.25,95%:1.54 - 3.30)、糖尿病(DM,=1.65,95%:1.17 - 2.32)、高体重指数(BMI,=1.06,95%:1.03 - 1.09)、高血清白蛋白水平(=1.04,95%:1.01 - 1.07)和磷水平(=3.12,95%:2.44 - 4.00)、低血清碳酸氢盐水平(=0.89,95%:0.87 - 0.92)、甘油三酯水平(=0.76,95%:0.68 - 0.85)和肌酐水平(=0.95,95%:0.90 - 0.99)、使用血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂(ACEI/ARB,=1.38,95%:1.11 - 1.72)和β受体阻滞剂(=1.32,95%:1.07 - 1.64)与高钾血症相关。20.7%的透析患者发生高钾血症。HD、DM、高BMI、高血清白蛋白和磷水平、低血清碳酸氢盐、甘油三酯和肌酐水平以及使用ACEI/ARB与高钾血症相关。

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