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TTF1阳性的SMARCA4/BRG1缺陷型肺腺癌

TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma.

作者信息

Mehta Anurag, Diwan Himanshi, Bansal Divya, Gupta Manoj

机构信息

Department of Laboratory, Molecular and Transfusion Services, Rajiv Gandhi Cancer Institute and Research Centre (RGCIRC), New Delhi, India.

Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre (RGCIRC), New Delhi, India.

出版信息

J Pathol Transl Med. 2022 Jan;56(1):53-56. doi: 10.4132/jptm.2021.09.16. Epub 2021 Nov 16.

DOI:10.4132/jptm.2021.09.16
PMID:34775734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8743805/
Abstract

SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non-small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.

摘要

与其他非小细胞肺癌相比，SMARCA4/BRG1缺陷型肺腺癌（SD-LUAD）因其临床、形态学和免疫表型特征的细微差异而被视为一种独特的亚型。我们在此报告一例SD-LUAD病例，该病例为形态学异质性肺腺癌，伴有甲状腺转录因子1（TTF1）表达异常。分化较好的区域保留了TTF1表达，而低分化肿瘤则出现TTF1表达缺失及BRG1普遍缺失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/16b220b81ac4/jptm-2021-09-16f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/497977475908/jptm-2021-09-16f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/cd83339d0f7b/jptm-2021-09-16f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/16b220b81ac4/jptm-2021-09-16f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/497977475908/jptm-2021-09-16f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/cd83339d0f7b/jptm-2021-09-16f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06e7/8743805/16b220b81ac4/jptm-2021-09-16f3.jpg

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2
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Arch Pathol Lab Med. 2021 Jan 1;145(1):90-98. doi: 10.5858/arpa.2019-0633-OA.
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