Wang Ziyuan, Yang Zihui, Liu Jie, Hao Yiming, Sun Baoguo, Wang Jing
China-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology & Business University, Beijing 100048, People's Republic of China.
J Agric Food Chem. 2021 Dec 1;69(47):14065-14074. doi: 10.1021/acs.jafc.1c05527. Epub 2021 Nov 13.
Mitochondria play an essential role in maintaining cellular metabolic homeostasis. However, its dysfunction will cause different pathophysiological consequences. A specific mechanism of action has been developed by cells to adapt to changes in physiological conditions or in response to different stimuli, by meditating mitochondrial number, structure, and energy metabolism. Whole grains are considered healthier than refined grains for their higher amounts of bioactive components, with proven multiple health benefits. The modulation of an appropriate mitochondrial function contributes to the bioactive-component-based health improvements. Thus, this review aims to represent current studies that identify the impact of natural bioactive components in whole grains against metabolic disorders by modulating mitochondrial biogenesis and energy metabolism. It seems most attractive to aim nutritional intervention at the prevention or treatment of metabolic abnormalities and hence to target dietary management at improvement of mitochondrial function.
线粒体在维持细胞代谢稳态中发挥着至关重要的作用。然而，其功能障碍会导致不同的病理生理后果。细胞已经形成了一种特定的作用机制，通过调节线粒体数量、结构和能量代谢，来适应生理条件的变化或对不同刺激作出反应。全谷物因其含有更高含量的生物活性成分而被认为比精制谷物更健康，已被证实具有多种健康益处。调节适当的线粒体功能有助于基于生物活性成分的健康改善。因此，本综述旨在介绍当前的研究，这些研究通过调节线粒体生物发生和能量代谢来确定全谷物中的天然生物活性成分对代谢紊乱的影响。将营养干预目标设定为预防或治疗代谢异常，从而将饮食管理目标设定为改善线粒体功能，这似乎最具吸引力。
