Department of Physiology, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Int J Mol Sci. 2021 Apr 27;22(9):4558. doi: 10.3390/ijms22094558.
Mitochondria play vital roles, including ATP generation, regulation of cellular metabolism, and cell survival. Mitochondria contain the majority of cellular nicotinamide adenine dinucleotide (NAD), which an essential cofactor that regulates metabolic function. A decrease in both mitochondria biogenesis and NAD is a characteristic of metabolic diseases, and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) orchestrates mitochondrial biogenesis and is involved in mitochondrial NAD pool. Here we discuss how PGC-1α is involved in the NAD synthesis pathway and metabolism, as well as the strategy for increasing the NAD pool in the metabolic disease state.
线粒体发挥着至关重要的作用，包括生成 ATP、调节细胞代谢和细胞存活。线粒体含有大部分细胞烟酰胺腺嘌呤二核苷酸 (NAD)，NAD 是一种调节代谢功能的必需辅助因子。线粒体生物发生和 NAD 的减少是代谢疾病的特征，过氧化物酶体增殖物激活受体 γ 共激活因子 1-α (PGC-1α) 协调线粒体生物发生并参与线粒体 NAD 库。本文讨论了 PGC-1α 如何参与 NAD 的合成途径和代谢，以及在代谢疾病状态下增加 NAD 库的策略。
