Epidemiology Unit, Division of Intramural Research, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Curr Med Res Opin. 2022 Feb;38(2):273-275. doi: 10.1080/03007995.2021.2006536. Epub 2021 Dec 6.
Congenital cytomegalovirus (CMV) is a leading cause of non-genetic sensorineural hearing loss and neurodevelopmental disabilities among US children. Studies using administrative healthcare databases have identified infants with congenital CMV using diagnostic codes from the International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification. Using Cerner Health Facts deidentified electronic health records, we assessed the sensitivity of CMV diagnostic codes among infants with laboratory confirmed congenital CMV infection (i.e. a positive CMV laboratory test - polymerase chain reaction, direct fluorescent antibody, or culture from urine, saliva, respiratory secretion or blood samples, or IgM serology - within 21 days of life). During 2010-2017, 668 congenital CMV cases were identified among 7,517,207 infants with encounters within 21 days of life, or 0.89 cases per 10,000 infants. The sensitivity of CMV diagnostic codes assigned within 21 and 90 days of life was 10.3% (95% CI: 8.2-12.9) and 11.1% (95% CI: 8.9-13.7), respectively.
先天性巨细胞病毒 (CMV) 是导致美国儿童非遗传性感觉神经性听力损失和神经发育障碍的主要原因。利用管理式医疗保健数据库的研究使用国际疾病分类第 9 版和第 10 版临床修订版中的诊断代码来识别患有先天性 CMV 的婴儿。我们使用 Cerner Health Facts 去识别电子健康记录，评估了实验室确诊的先天性 CMV 感染婴儿（即出生后 21 天内尿液、唾液、呼吸道分泌物或血液样本的 CMV 实验室检测阳性 - 聚合酶链反应、直接荧光抗体或培养，或 IgM 血清学 -）的 CMV 诊断代码的敏感性。在 2010 年至 2017 年期间，在 7517207 名出生后 21 天内有就诊记录的婴儿中发现了 668 例先天性 CMV 病例，每 10000 名婴儿中有 0.89 例。出生后 21 天和 90 天内分配的 CMV 诊断代码的敏感性分别为 10.3%（95%CI：8.2-12.9）和 11.1%（95%CI：8.9-13.7）。
