Rahbar Maryam, Rahimzadeh Hormat, Aghsaeifard Ziba, Bagherpour Farzaneh, Namdari Farshad, Latifi Marzieh, Dialameh Hosein, Taheri Mahmoudi Mohsen, Niroumand Jalai Mona, Dehghani Sanaz
From the Department of Nephrology, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Exp Clin Transplant. 2022 Feb;20(2):130-135. doi: 10.6002/ect.2021.0313. Epub 2021 Nov 10.
COVID-19 has been spreading rapidly throughout the world, with nearly every country thus far documenting this infection. In this study, our aim was to evaluate the risk factors for increased mortality in deceased donor kidney transplant recipients with COVID-19 at a single center in Iran.
This was a retrospective study in a single center. During the 17-month ongoing COVID19 pandemic in Iran, there were 153 deceased donor kidney recipients at our center with suspected COVID19 symptoms. Of these patients, 138 had positive COVID-19 tests, and thus a therapeutic regimen was commenced for these patients. Data were analyzed with SPSS version 16 software.
The patients were predominantly male (83, 60.1%) with a median age of 47.09 ± 13.75 years and a median time since transplant of 51 months (IQR, 1-276 months). Among these patients, 84 (60.8%) had hypertension and 43 (31.2%) had diabetes mellitus. We observed a significant relationship between disease severity and mortality (P < .001). After risk adjustments for age, presence of diabetes mellitus and hypertension and blood group type were factors that showed a significantly higher risk of death.
Deceased donor kidney transplant recipients with confirmed COVID-19 experienced less fever as an initial symptom. However, recipients with COVID-19 and an underlying disease had a higher rate of mortality, severity of infection, and progression of disease. Appropriate management of renal complications and vaccinations in deceased donor kidney transplant recipients may help lead to more favorable outcomes.
新型冠状病毒肺炎（COVID-19）已在全球迅速传播，迄今为止几乎每个国家都记录了这种感染情况。在本研究中，我们的目的是评估伊朗一个单一中心的COVID-19死亡供体肾移植受者死亡率增加的危险因素。
这是一项在单一中心进行的回顾性研究。在伊朗持续17个月的COVID-19大流行期间，我们中心有153名死亡供体肾移植受者出现疑似COVID-19症状。在这些患者中，138例COVID-19检测呈阳性，因此对这些患者开始了治疗方案。使用SPSS 16版软件进行数据分析。
患者以男性为主（83例，60.1%），中位年龄为47.09±13.75岁，移植后的中位时间为51个月（四分位间距，1 - 276个月）。在这些患者中，84例（60.8%）患有高血压，43例（31.2%）患有糖尿病。我们观察到疾病严重程度与死亡率之间存在显著关系（P <.001）。在对年龄、糖尿病和高血压的存在以及血型进行风险调整后，这些因素显示出显著更高的死亡风险。
确诊COVID-19的死亡供体肾移植受者最初症状发热较少。然而，患有COVID-19且有基础疾病的受者死亡率、感染严重程度和疾病进展率较高。对死亡供体肾移植受者的肾脏并发症进行适当管理和接种疫苗可能有助于获得更有利的结果。
