Eggena P, Barrett J D, Fredal A M, Morin A M
Renin Biochemistry Laboratory, Veterans Administration Medical Center, Sepulveda, California 91343.
J Hypertens Suppl. 1987 Jul;5(2):S11-3. doi: 10.1097/00004872-198707002-00003.
The influence of central and peripheral injections of dexamethasone and 17 beta-oestradiol on plasma, brain and aortic renin substrate was studied in the rat. Whereas intraperitoneal or intravenous injection of these steroids raised renin substrate in plasma, brain and the aorta, intraventricular injection raised it only in the brain and aorta. Bilateral nephrectomy produced results equivalent to those observed following intraperitoneal administration of steroids. Dissociation of the plasma and tissue renin-substrate levels in response to central administration of steroids indicates local synthesis of this protein, possibly under central control.
研究了向大鼠中枢和外周注射地塞米松和17β-雌二醇对血浆、脑和主动脉肾素底物的影响。腹腔内或静脉内注射这些类固醇会使血浆、脑和主动脉中的肾素底物升高，而脑室内注射仅使脑和主动脉中的肾素底物升高。双侧肾切除产生的结果与腹腔内注射类固醇后观察到的结果相当。对类固醇中枢给药时血浆和组织肾素底物水平的分离表明该蛋白可能在中枢控制下进行局部合成。
