Jiayu Liu, Jing Sun, Yiyang Chen, Fan Li
Oral and Maxillofacial Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Clinical Nutrition Department, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Front Pediatr. 2021 Oct 29;9:771333. doi: 10.3389/fped.2021.771333. eCollection 2021.
By comparing and studying the changes of food intake, weight, body length, BMI, blood albumin level and other indicators of infants with Pierre-Robin Sequence (PRS) before and after Bilateral Mandible Distraction Osteogenesis operation, to explore the effect of distraction osteogenesis on PRS patients about the improvement of nutrition status. The children with PRS who admitted to the Oral and Maxillofacial Surgery Department of Guangzhou Women and Children's Medical Center from July 2015 to December 2020 were selected. All patients accepted bilateral mandible distraction osteogenesis surgery, and the pre- and post-operative indicators were recorded, such as food intake, weight, length, blood albumin level and others. BMI was calculated based on the indicators mentioned above, and comparative statistical analysis was performed. 1. All patients were fed with whole milk before the first surgery, and the average calorie per kg was 91.8 kcal/kg, significantly lower than the standard (100-150 kcal/kg), suggesting the overall nutritional intake of PRS patients is low; 2. tests for independent samples were used to analyze the pre-operative and post-operative indicators. The WFA percentile increased from 14.16 ± 2.17 to 15.01 ± 1.85% ( = 0.0048), WFA score increased from -2.40 ± 0.18 to -1.90 ± 0.14 after the surgery ( = 0.0010), LFA percentile increased from 20.04 ± 3.48 to 33.67 ± 4.29% ( = 0.0098), LFA z score increased from -2.09 ± 0.19 to -1.42 ± 0.23 ( = 0.0009), BMI score increased from -1.95 ± 0.22 to -1.39 ± 0.16 ( = 0.0408), ALB raised from 37.06 ± 0.51 to 42.85 ± 0.30 g/L ( < 0.001), which indicating that the physique of patients improved after the distraction osteogenesis surgery, mainly was reflected by the lifting of weight and length growth curves; the body shape also improved, indicating that the patients' nutrition status after the surgery is also improved. Bilateral mandible distraction osteogenesis surgery has a positive effect on the nutrition status of children with PRS. This effect is mainly reflected by the improvements of the body physical indicators after surgery.
通过比较和研究患有皮埃尔 - 罗宾序列征（PRS）的婴儿在双侧下颌骨牵张成骨手术前后的食物摄入量、体重、身长、BMI、血白蛋白水平等指标的变化，探讨牵张成骨对PRS患者营养状况改善的影响。选取2015年7月至2020年12月在广州妇女儿童医疗中心口腔颌面外科住院的PRS患儿。所有患者均接受双侧下颌骨牵张成骨手术，并记录术前和术后指标，如食物摄入量、体重、身长、血白蛋白水平等。根据上述指标计算BMI，并进行比较统计分析。1. 所有患者在首次手术前均喂食全脂牛奶，每千克平均热量为91.8千卡/千克，显著低于标准值（100 - 150千卡/千克），提示PRS患者总体营养摄入量较低；2. 采用独立样本检验分析术前和术后指标。术后体重增长曲线百分位数从14.16±2.17增加到15.01±1.85%（P = 0.0048），体重增长曲线评分从 - 2.40±0.18增加到 - 1.90±0.14（P = 0.0010），身长增长曲线百分位数从20.04±3.48增加到33.67±4.29%（P = 0.0098），身长增长曲线z评分从 - 2.09±0.19增加到 - 1.42±0.23（P = 0.0009），BMI评分从 - 1.95±0.22增加到 - 1.39±0.16（P = 0.0408），白蛋白从37.06±0.51升高到42.85±0.30克/升（P < 0.001），这表明牵张成骨手术后患者体质改善，主要体现在体重和身长增长曲线的上升；体型也得到改善，表明手术后患者的营养状况也得到改善。双侧下颌骨牵张成骨手术对PRS患儿的营养状况有积极影响。这种影响主要体现在手术后身体各项指标的改善上。
