Mäkinen J, Salmi T, Grönroos M
Department of Obstetrics and Gynecology, University Central Hospital, Turku, Finland.
Ann Chir Gynaecol Suppl. 1987;202:68-71.
In 63 patients with invasive vulvar squamous cell cancer treatment was individualized according to patient tolerance: surgery was less mutilating than conventionally, while radio and chemotherapy was given judiciously. The overall 5-year crude survival rate was 43.5%, while the most common treatment (bleomycin, electroexcision and irradiation) had a 5-year survival rate of 55.2%. The rate of complications was low, although most of the patients were of advanced age and had intercurrent diseases. Although the therapy we applied most often yielded moderately satisfactory results it would appear according to the literature that marginal tumor excision accompanied with inguinal lymph node dissection could still improve patient outcome. This strategy could also include predictive testing of sensitivity of the tumors to cytostatics.
对于63例浸润性外阴鳞状细胞癌患者，治疗方案根据患者耐受性进行个体化调整：手术造成的毁伤比传统手术小，同时合理给予放疗和化疗。5年总粗生存率为43.5%，而最常用的治疗方法（博来霉素、电切除和放疗）的5年生存率为55.2%。尽管大多数患者年龄较大且伴有其他疾病，但并发症发生率较低。虽然我们最常采用的治疗方法取得了较为满意的效果，但根据文献显示，边缘性肿瘤切除联合腹股沟淋巴结清扫仍可能改善患者的预后。该策略还可包括对肿瘤对细胞抑制剂敏感性的预测性检测。
