Centre for Crisis Psychology, Faculty of Psychology, University of Bergen, Møllendalsbakken 9, N - 5009, Bergen, Norway.
Hyperbaric Medicine Unit, Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
Support Care Cancer. 2022 Mar;30(3):2477-2486. doi: 10.1007/s00520-021-06684-x. Epub 2021 Nov 15.
Curative radiotherapy for cancer may lead to severe late radiation tissue injuries (LRTIs). However, limited knowledge exists about pelvic cancer survivors' LRTI symptoms, distress, and health-related quality of life (HRQOL). We sought to assess the symptom burden, distress, and HRQOL in survivors with established pelvic LRTIs compared to norm populations and to investigate the relation between these factors.
Cancer survivors referred for treatment of established pelvic LRTIs were recruited nationwide. LTRIs were assessed with the Expanded Prostate Cancer Index Composite (EPIC), psychological distress was assessed with the General Health Questionnaire (GHQ-12), and HRQOL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORCT-QLQ-C30).
A total of 107 participants (mean age 64, 53% men) were included. Compared to norms, participants reported more urinary (mean 68.7 vs. 89.5; p = 0.00; d = 1.4) and bowel symptoms (mean 62.5 vs. 92.4; p = 0.00; d = 2.7), increased psychological distress (mean 13.4 vs. 10.3; p = 0.00; d = 0.6), and overall poorer HRQOL (mean 54.9 vs. 71.2; p = 0.00; d = 0.7). Higher symptom burden and higher levels of psychological distress were associated with lower HRQOL (r = 46%), but psychological distress did not moderate the influence of symptoms on HRQOL.
Cancer survivors with established pelvic LRTIs are highly burdened compared to norms. The association of the LRTI-related symptom burden with HRQOL is independent of the level of psychological distress. Both coping and treatment interventions are crucial to promoting long-term health and HRQOL.
NCT03570229.
癌症的根治性放疗可能导致严重的晚期放射性组织损伤（LRTIs）。然而，对于患有晚期盆腔放射性损伤的癌症幸存者的 LRTI 症状、痛苦和健康相关生活质量（HRQOL），我们的了解非常有限。本研究旨在评估与正常人群相比，患有晚期盆腔 LRTIs 的癌症幸存者的症状负担、痛苦和 HRQOL，并探讨这些因素之间的关系。
在全国范围内招募因晚期盆腔 LRTIs 接受治疗的癌症幸存者。使用扩展前列腺癌指数综合量表（EPIC）评估 LRTIs，使用一般健康问卷（GHQ-12）评估心理困扰，使用欧洲癌症研究与治疗组织生活质量问卷（EORCT-QLQ-C30）评估 HRQOL。
共纳入 107 名参与者（平均年龄 64 岁，53%为男性）。与正常人群相比，参与者报告的尿失禁（平均 68.7 对 89.5；p = 0.00；d = 1.4）和肠失禁症状（平均 62.5 对 92.4；p = 0.00；d = 2.7）更多，心理困扰更严重（平均 13.4 对 10.3；p = 0.00；d = 0.6），整体 HRQOL 更差（平均 54.9 对 71.2；p = 0.00；d = 0.7）。更高的症状负担和更高水平的心理困扰与更低的 HRQOL 相关（r = 46%），但心理困扰并不能调节症状对 HRQOL 的影响。
与正常人群相比，患有晚期盆腔 LRTIs 的癌症幸存者负担沉重。LRTI 相关症状负担与 HRQOL 的相关性独立于心理困扰水平。应对和治疗干预对于促进长期健康和 HRQOL 都至关重要。
NCT03570229。
Zotero 插件