The polycystic ovary. I. Estradiol/testosterone ratio and the use of antiestrogens.

Several treatments have been used to induce ovulation in the polycystic ovary. In the following study, estradiol and testosterone plasma concentration were measured and evaluated in 18 women with polycystic ovaries, as one of the factors involved in the antiestrogenic response to Clomiphene Citrate. An estrogen plasma concentration baseline of 50 pg/ml is proposed in order to obtain the antiestrogenic effects. Nevertheless, induction of ovulation was achieved when the estradiol/testosterone ratio was 0.09 or higher (P less than 0.001).