在联合治疗时代，HIV 感染成人的认知和抑郁的可溶性生物标志物。
Soluble Biomarkers of Cognition and Depression in Adults with HIV Infection in the Combination Therapy Era.
机构信息
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 341 Ponce de Leon Avenue, Atlanta, GA, 30308, USA.
University at Buffalo, Buffalo, NY, USA.
出版信息
Curr HIV/AIDS Rep. 2021 Dec;18(6):558-568. doi: 10.1007/s11904-021-00581-y. Epub 2021 Nov 15.
PURPOSE OF REVIEW
Cognitive impairment and depression continue to be common among people with HIV (PWH) in the combination antiretroviral therapy (ART) era. A better understanding of the biological mechanisms that may underpin these disorders is needed. The purpose of this review is to describe published findings on soluble biomarkers from blood and cerebrospinal fluid (CSF) that have been associated with either cognition or depression among PWH in the setting of ART.
RECENT FINDINGS
Several biomarkers, including those that reflect viral persistence, monocyte/macrophage activation, and other processes, are associated with cognition and depressive symptoms. Some but not all results have been consistent across multiple studies. More research has been published on biomarkers of cognition relative to biomarkers of depression (particularly from CSF). More studies are needed that investigate multiple biomarkers to understand the role of distinct but additive pathways in these disorders and to guide the development of new therapies.
目的综述
在联合抗逆转录病毒疗法（ART）时代，认知障碍和抑郁仍是 HIV 感染者（PWH）的常见问题。需要更好地了解可能构成这些疾病基础的生物学机制。本综述的目的是描述与接受 ART 的 PWH 的认知或抑郁相关的血液和脑脊液（CSF）可溶性生物标志物的已发表研究结果。
最近的发现
多种生物标志物，包括反映病毒持续存在、单核细胞/巨噬细胞激活和其他过程的生物标志物，与认知和抑郁症状有关。但并非所有结果在多项研究中都一致。与抑郁生物标志物（特别是 CSF 中的生物标志物）相比，已有更多关于认知生物标志物的研究发表。需要开展更多研究，以调查多种生物标志物，以了解这些疾病中不同但可累加的途径的作用，并指导新疗法的开发。
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