Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Mol Carcinog. 2022 Feb;61(2):243-253. doi: 10.1002/mc.23372. Epub 2021 Nov 15.
Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to generate cellular energy during times of stress. Recycling of these cellular components occurs in a series of sequential steps with multiple regulatory points. Mechanistic dysfunction can lead to a variety of human diseases and cancers due to the complexity of autophagy and its ability to regulate vital cellular functions. The role that autophagy plays in both the development and treatment of cancer is highly complex, especially given the fact that most cancer therapies modulate autophagy. This review aims to discuss the balance of autophagy in the development, progression, and treatment of head and neck cancer, as well as highlighting the need for a deeper understanding of what is still unknown about autophagy.
自噬是一种进化上保守的细胞存活机制，可在应激时降解受损的蛋白质和细胞器以产生细胞能量。这些细胞成分的再循环发生在具有多个调节点的一系列连续步骤中。由于自噬的复杂性及其调节重要细胞功能的能力，机械功能障碍可导致多种人类疾病和癌症。自噬在癌症的发展和治疗中的作用非常复杂，特别是因为大多数癌症疗法都调节自噬。本综述旨在讨论自噬在头颈部癌症的发展、进展和治疗中的平衡，并强调需要更深入地了解自噬仍然未知的方面。
