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一种多功能 salecan/结冷胶凝胶基质的流变学研究。

Rheological investigation of a versatile salecan/curdlan gel matrix.

机构信息

Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.

Liaocheng High-Tech Biotechnology Co., Ltd, Liaocheng 252059, China.

出版信息

Int J Biol Macromol. 2021 Dec 15;193(Pt B):2202-2209. doi: 10.1016/j.ijbiomac.2021.11.051. Epub 2021 Nov 13.

Abstract

Hydrogel, as a three-dimensional material with high water content, has unique physicochemical and variable mechanical properties. Natural polysaccharide-based composite hydrogels are very popular within medical industry as these viscoelastic materials are non-toxic, biodegradable, bioabsorbable, and biocompatible. This research investigates the engineering of novel composite hydrogels from natural polysaccharides salecan and curdlan without any structural modification and chemical crosslinking. The scanning electron microscopy, Fourier transform infrared spectroscopy and various rheological methods were employed to investigate the morphology, molecular interaction, and flow behavior of the samples respectively. The key rheological parameters were compared using the Power Law, Herschel-Bulkley and Arrhenius models. This is the first study reporting a novel composite hydrogel made from Salecan and Curdlan with ideal elasticity, enhanced thermostability, good injectability, self-recovery and other rheological properties that will pave the way for application in different fields.

摘要

水凝胶作为一种高含水量的三维材料,具有独特的物理化学性质和可变的机械性能。天然多糖基复合水凝胶在医学领域非常受欢迎,因为这些黏弹性材料是无毒、可生物降解、可生物吸收和生物相容的。本研究旨在不进行任何结构修饰和化学交联的情况下,从天然多糖沙菜聚糖和琼脂糖制备新型复合水凝胶。扫描电子显微镜、傅里叶变换红外光谱和各种流变学方法分别用于研究样品的形态、分子相互作用和流动行为。使用幂律、赫谢尔-布尔克利和阿伦尼乌斯模型比较了关键流变学参数。这是首例报道沙菜聚糖和琼脂糖制备新型复合水凝胶的研究,该水凝胶具有理想的弹性、增强的热稳定性、良好的可注射性、自恢复性和其他流变学性能,为其在不同领域的应用铺平了道路。

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