新发难治性癫痫持续状态（NORSE）：女王广场神经重症监护室的经验。
New-Onset Refractory Status Epilepticus (NORSE): The Queen Square Neuro-ICU experience.
机构信息
UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Homerton University Hospital NHS Foundation Trust, Homerton Row, London E9 6SR, UK.
UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
出版信息
Epilepsy Behav. 2021 Dec;125:108387. doi: 10.1016/j.yebeh.2021.108387. Epub 2021 Nov 12.
The introduction and widespread adoption of the term 'NORSE' - new-onset refractory status epilepticus - raises both fundamental conceptual and pragmatic questions. We studied a cohort of patients with 'NORSE' at the National Hospital for Neurology and Neurosurgery to investigate the clinical features, treatment responses, and outcomes with a focus on sub-group analysis. We identified 26 cases of 'NORSE'. There was no difference in prognosis between 'NORSE' and non-'NORSE' RSE, nor in any sub-analysis in the 'NORSE' cohort. We discuss the utility and validity of the term NORSE as a descriptor for a subgroup with RSE in whom the underlying etiologies are heterogeneous and pathophysiological mechanisms are unknown.
术语“NORSE”（新发难治性癫痫持续状态）的引入和广泛应用引发了一些基本的概念和实际问题。我们在国家神经病学和神经外科学院研究了一组患有“NORSE”的患者，以调查其临床特征、治疗反应和结果，并特别关注亚组分析。我们共发现 26 例“NORSE”患者。“NORSE”与非“NORSE”RSE 患者的预后无差异，“NORSE”患者的任何亚组分析也无差异。我们讨论了“NORSE”一词作为 RSE 亚组的描述符的效用和有效性，该亚组的潜在病因具有异质性，病理生理机制尚不清楚。
Zotero 插件