Department of Animal Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Department of Veterinary Medicine and Animal Welfare, University of Santo Amaro, São Paulo, São Paulo, Brazil.
Homeopathy. 2022 May;111(2):134-138. doi: 10.1055/s-0041-1732352. Epub 2021 Nov 15.
Ovariohysterectomy (OH) is one of the most frequent elective surgical procedures in routine veterinary practice. is a well-known medicine in phytotherapy, with proven analgesic, anti-inflammatory, antiseptic, healing, antioxidant and immunomodulatory activity. However, there is still a shortage of studies on the action and effects of the homeopathic formulation of the medicine on animals. The aim of this study was to evaluate analgesia with 30cH during the postoperative period after elective OH.
Thirty healthy female dogs, aged 1 to 3 years, weighing 7 to 14 kg, were selected at the Veterinary Hospital in Campo Mourão, Paraná, Brazil. The dogs underwent the surgical procedure with an anaesthetic protocol and analgesia that had the aim of maintaining the patient's wellbeing. After the procedure, they were randomly divided into three groups of 10. One group received 30cH; another received 5% hydroalcoholic solution; and the third group, 0.9% NaCl saline solution. All animals received four drops of the respective solution sublingually and under blinded conditions, every 10 minutes for 1 hour, after the inhalational anaesthetic had been withdrawn. The Glasgow Composite Measure Pain Scale was used to analyse the effect of therapy. Analysis of variance (ANOVA) followed by the Tukey test was used to evaluate the test data. Statistical differences were deemed significant when ≤0.05.
The 30cH group maintained analgesia on average for 17.8 ± 3.6 hours, whilst the hydroalcoholic solution group did so for 5.1 ± 1.2 hours and the saline solution group for 4.1 ± 0.9 hours ( ≤0.05).
These data demonstrate that 30cH presented a more significant analgesic effect than the control groups, thus indicating its potential for postoperative analgesia in dogs undergoing OH.
卵巢子宫切除术(OH)是常规兽医实践中最常见的择期手术之一。 是植物疗法中一种众所周知的药物,具有已证实的镇痛、抗炎、防腐、愈合、抗氧化和免疫调节作用。然而,关于该药物的顺势疗法制剂对动物的作用和影响的研究仍然缺乏。本研究旨在评估 30cH 在 OH 术后期间的镇痛作用。
在巴西坎波莫朗的兽医医院选择了 30 只健康的雌性犬,年龄为 1 至 3 岁,体重为 7 至 14 公斤。这些犬接受了手术程序和镇痛的麻醉方案,旨在维持患者的舒适度。手术后,它们被随机分为三组,每组 10 只。一组接受 30cH;另一组接受 5%的水醇溶液;第三组接受 0.9%的生理盐水溶液。所有动物在吸入麻醉剂撤回后,在盲法条件下每 10 分钟舌下给予相应溶液 4 滴,持续 1 小时。使用格拉斯哥综合疼痛量表分析治疗效果。采用方差分析(ANOVA),然后采用 Tukey 检验对测试数据进行评估。当 ≤0.05 时,认为存在统计学差异。
30cH 组的平均镇痛时间为 17.8 ± 3.6 小时,而水醇溶液组为 5.1 ± 1.2 小时,生理盐水溶液组为 4.1 ± 0.9 小时( ≤0.05)。
这些数据表明,30cH 比对照组表现出更显著的镇痛效果,表明其在接受 OH 的犬中具有术后镇痛的潜力。