Department of Chemistry, Indian Institute of Technology Madras, Chennai, India.
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.
Chem Commun (Camb). 2021 Nov 25;57(94):12695-12698. doi: 10.1039/d1cc05652b.
A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The 30 nm-sized dendrimer nanomicelles successfully entrapped Doxorubicin, demonstrated the sustained release of Doxorubicin and can successfully penetrate cancer cells through caveolae-dependent endocytosis, compared to the free drug.
一种合理设计的两亲性聚（芳基醚）基树状大分子自组装成纳米胶束，并在改变亲水性链长时表现出可调节的形态。与游离药物相比，30nm 大小的树状大分子纳米胶束成功包载了阿霉素，并表现出阿霉素的持续释放，并且可以通过网格蛋白依赖的内吞作用成功穿透癌细胞。
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