University of Colorado Denver, 1201 Larimer Street, Campus Box 173, Denver, CO, 80204, USA.
Arch Gynecol Obstet. 2022 Sep;306(3):707-715. doi: 10.1007/s00404-021-06318-x. Epub 2021 Nov 15.
Subtypes of depression have been under studied in women during the peripartum period and the year after childbirth and delivery. Due to heterogeneity of depression, researchers have attempted to identify phenotypes of maternal and postpartum depression based on key symptoms that may represent underlying genes and biological etiology (Leuchter et al. Dialog Clinic Neurosci 16(4):525, 2014).
The current study collected self-report data from 587 women and utilized exploratory and confirmatory factor analyses (CFA) to identify subtypes of depression symptoms across two measures.
Findings of the study showed that: (1) using the Beck Depression Inventory (BDI-II) and the Postpartum Depression Screening Scale (PDSS), a five-factor solution best fit the data in our sample of mothers with infants aged 4-14 months. The factors included: anxiety/thought disorder; cognitive depression; suicide; somatic/neurovegetative; and sleep [χ (454, N = 587) = 1102.61, p < 0.001, comparative fit index (CFI) = 0.93, Tucker Lewis index (TLI) = 0.92, root mean square error of approximation (RMSEA) = 0.05]; and (2) the following factors significantly positively predicted interview-based diagnosis of depression: cognitive symptoms of depression and sleep [χ (482, N = 587) = 1170.40, p < 0.001, TLI = 0.91, CFI = 0.93, RMSEA = 0.05].
Future research could assess the clinical benefits of screening for maternal mood disorders.
在围产期和产后一年期间,对女性产后抑郁症的亚型进行了研究。由于抑郁症的异质性,研究人员试图根据可能代表潜在基因和生物学病因的关键症状来确定母亲和产后抑郁症的表型(Leuchter 等人,Dialog Clinic Neurosci 16(4):525,2014)。
本研究从 587 名女性中收集了自我报告数据,并利用探索性和验证性因子分析(CFA)来识别两个测量指标上的抑郁症状亚型。
研究结果表明:(1)使用贝克抑郁量表(BDI-II)和产后抑郁筛查量表(PDSS),五因素解决方案最适合我们的婴儿年龄为 4-14 个月的母亲样本。这些因素包括:焦虑/思维障碍;认知抑郁;自杀;躯体/神经植物性;和睡眠[χ(454,N=587)=1102.61,p<0.001,比较拟合指数(CFI)=0.93,Tucker Lewis 指数(TLI)=0.92,均方根误差近似值(RMSEA)=0.05];(2)以下因素显著正向预测基于访谈的抑郁症诊断:认知抑郁症状和睡眠[χ(482,N=587)=1170.40,p<0.001,TLI=0.91,CFI=0.93,RMSEA=0.05]。
未来的研究可以评估筛查产妇情绪障碍的临床益处。