在意大利北部 COVID-19 大流行期间，对 SARS-CoV-2 抗体进行筛查的患者中肾移植排斥率。
Kidney transplant rejection rate in screened patients for anti-SARS-CoV-2 antibodies, during COVID-19 pandemic in Northern Italy.
机构信息
Unit of Nephrology, Dialysis and Transplantation, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
Molecular Virology Unit, Microbiology and Virology Department Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
出版信息
New Microbiol. 2021 Jul;44(3):184-186.
Coronavirus is a high-risk pathogen for kidney transplant recipients receiving immunosuppressive therapy; Coronavirus disease 2019 (COVID-19) is an infection causing severe acute respiratory syndrome (SARS-CoV2), and progressive withdrawal of immunosuppressive drugs has been suggested in transplanted patients. At IRCCS San Matteo Hospital in Pavia, Northern Italy, during the pandemic we performed a screening and all transplanted patients were evaluated for IgG anti SARS-CoV-2; 12 of 201 kidney transplant recipients (6%) screened for IgG anti SARS-CoV-2 (s) developed kidney transplant rejection; 10 (83%) were negative and 2 (17%) resulted positive for SARS-CoV-2 IgG, while among 189 patients without rejection, 162 (86%) resulted negative and 27 (14%) positive (P=0.69). COVID 19 course may be more severe in kidney transplant recipients but it does not significantly increase risk of kidney rejection.
冠状病毒是接受免疫抑制治疗的肾移植受者的高风险病原体；2019 年冠状病毒病（COVID-19）是一种引起严重急性呼吸系统综合征（SARS-CoV2）的感染，已建议在移植患者中逐渐停用免疫抑制药物。在意大利北部帕维亚的 IRCCS San Matteo 医院，在大流行期间，我们进行了筛查，所有移植患者都接受了 IgG 抗 SARS-CoV-2 检测；在筛查 IgG 抗 SARS-CoV-2 的 201 例肾移植受者中（6%），有 12 例（83%）为阴性，2 例（17%）为 SARS-CoV-2 IgG 阳性，而在 189 例无排斥反应的患者中，有 162 例（86%）为阴性，27 例（14%）为阳性（P=0.69）。COVID-19 病程在肾移植受者中可能更为严重，但不会显著增加肾排斥反应的风险。
Zotero 插件