McFall W T, Hamrick S W
School of Dentistry, University of North Carolina, Chapel Hill 27514.
J Periodontol. 1987 Oct;58(10):701-5. doi: 10.1902/jop.1987.58.10.701.
Four test dentifrices were evaluated in a double-blind investigation to determine their effect on dentinal sensitivity in 87 adult human participants. Baseline data were obtained by patient questionnaire, dental examination and by soliciting subjective responses to controlled osmotic, thermal and tactile stimuli. The four dentifrices were: (1) a placebo dentifrice, (2) a fluoride dentifrice containing 0.1% fluoride, (3) a 2% citrate buffered dentifrice in a pluronic gel and (4) a dentifrice containing 0.1% fluoride and 2% citrate buffer in a pluronic gel. Precipitated silica provided the abrasive for all dentifrices. Dentifrices were supplied to participants on a random basis, and participants were instructed to brush twice daily for 8 weeks. Responses to the three stimuli as accomplished at baseline were obtained at 2, 4 and 8 weeks on 81 participants. A statistically significant stimulus reduction was found between treatment groups to thermal stimulus at the 2-month interval (P = 0.048) and to the tactile stimulus at 2 weeks (P = 0.019). Both the citrate dentifrice and the citrate/fluoride dentifrices demonstrated significant efficiency in reducing sensitivity.
在一项双盲研究中对四种试验牙膏进行了评估，以确定它们对87名成年人类受试者牙本质敏感的影响。通过患者问卷、牙科检查以及征求对可控渗透、热和触觉刺激的主观反应来获取基线数据。这四种牙膏分别是：（1）一种安慰剂牙膏，（2）一种含0.1%氟化物的氟化物牙膏，（3）一种在普朗尼克凝胶中的2%柠檬酸盐缓冲牙膏，以及（4）一种在普朗尼克凝胶中含0.1%氟化物和2%柠檬酸盐缓冲剂的牙膏。沉淀二氧化硅为所有牙膏提供研磨剂。牙膏随机提供给受试者，受试者被指示每天刷牙两次，持续8周。在第2、4和8周时，对81名受试者获取了与基线时相同的对三种刺激的反应。在2个月的间隔时，治疗组之间对热刺激的反应有统计学显著降低（P = 0.048），在2周时对触觉刺激的反应有统计学显著降低（P = 0.019）。柠檬酸盐牙膏和柠檬酸盐/氟化物牙膏在降低敏感度方面均显示出显著效果。
