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新型冠状病毒肺炎与鼻脑型毛霉菌病的关联:一项观察性研究。

Association of COVID-19 with Rhino-Cerebral Mucormycosis: An Observational Study.

作者信息

Agarwal Varsha, Gupta Ambika, Singh Virendra, Jajodia Neha, Popli Harsha, Akilan R

机构信息

Dept. of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Room No. 11, Rohtak, 124001 India.

Dept. Of Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India.

出版信息

J Maxillofac Oral Surg. 2022 Sep;21(3):990-994. doi: 10.1007/s12663-021-01665-3. Epub 2021 Nov 11.

Abstract

Mucormycosis is becoming more common in patients infected with or recovering from COVID-19 under the current situation. However, there is a scarcity of research on a specific group of COVID-19 individuals who are predisposed to mucormycosis. As a result, a retrospective observational study was undertaken to assess the possible connection of mucormycosis with COVID-19. The goal was also to investigate the link between diabetes mellitus, mucormycosis and COVID-19. The occurrence and severity of the disease among the case records were assessed using signs and symptoms, investigations conducted during COVID-19, and serological test results. Patients were classified as previously known diabetics, recently diagnosed diabetics, or non-diabetics based on their history of pre-existing DM and HBA1c levels at the time of reporting for mucormycosis. The findings show that mild COVID-19-infected patients and non-diabetic patients have a high incidence of COVID-19-associated mucormycosis (CAM). As a result, all clinicians participating in the care of COVID-infected patients must be aware of the significant risk of secondary mucormycosis in the post-recovery phase, even in those with mild or moderate symptoms.

摘要

在当前形势下,毛霉菌病在感染新冠病毒或从新冠病毒感染中恢复的患者中越来越常见。然而,对于易患毛霉菌病的特定新冠病毒感染人群的研究却很匮乏。因此,开展了一项回顾性观察研究,以评估毛霉菌病与新冠病毒感染之间的可能联系。研究目标还包括调查糖尿病、毛霉菌病和新冠病毒感染之间的关联。通过症状体征、新冠病毒感染期间进行的检查以及血清学检测结果,评估病例记录中疾病的发生情况和严重程度。根据患者既往糖尿病史以及报告毛霉菌病时的糖化血红蛋白水平,将患者分为既往已知糖尿病患者、近期诊断的糖尿病患者或非糖尿病患者。研究结果表明,轻度新冠病毒感染患者和非糖尿病患者发生新冠病毒相关毛霉菌病(CAM)的几率较高。因此,所有参与新冠病毒感染患者护理的临床医生都必须意识到,即使是症状轻微或中度的患者,在康复后期也存在继发毛霉菌病的重大风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6ca/9474771/fd7ef894650a/12663_2021_1665_Fig1_HTML.jpg

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