Mora-Martínez Alejandro, Murcia Laura, Rodríguez-Lozano Francisco Javier
Department of Special Care in Dentistry, Hospital Morales Meseguer, IMIB-Arrixaca, University of Murcia, 30008 Murcia, Spain.
Department of Health Sciences, Catholic University San Antonio of Murcia, 30107 Murcia, Spain.
J Fungi (Basel). 2023 Sep 16;9(9):935. doi: 10.3390/jof9090935.
Mucormycosis is a rare, opportunistic, and emerging fungal infection that can rapidly develop into a severe, highly fatal clinical picture. In most cases, it is caused by fungi of the order Mucorales, which are usually avirulent but become pathogenic when the host's immune system is compromised. This systematic review was conducted according to PRISMA guidelines. The databases searched included PubMed, Scopus, and Web of Science. We chose articles that analyzed the oral manifestations of patients with mucormycosis, were published between 2018 and 2023, and met our search terms. The risk of bias in the articles was assessed using the CARE guideline for case reports and STROBE for a cross-sectional study. After the selection process, 20 articles were included in this review, all containing information about the different oral manifestations presented by people with mucormycosis. The most common oral manifestations are mainly bone exposures and oral ulcers, halitosis, pus discharge, gingival thickening, and periodontitis. However, despite the importance of recognizing these oral manifestations in the early stages of mucormycotic infection, providing early treatment, and reducing the high mortality rate of the infection, more studies are needed.
毛霉病是一种罕见的、机会性的、正在出现的真菌感染，可迅速发展为严重的、高致死率的临床病症。在大多数情况下，它由毛霉目真菌引起，这些真菌通常无致病性，但在宿主免疫系统受损时会变得致病。本系统评价是根据PRISMA指南进行的。检索的数据库包括PubMed、Scopus和科学网。我们选择了2018年至2023年期间发表的、分析毛霉病患者口腔表现且符合我们检索词的文章。使用病例报告的CARE指南和横断面研究的STROBE对文章中的偏倚风险进行评估。经过筛选过程，本评价纳入了20篇文章，所有文章均包含毛霉病患者出现的不同口腔表现的信息。最常见的口腔表现主要是骨暴露、口腔溃疡、口臭、脓性分泌物、牙龈增厚和牙周炎。然而，尽管在毛霉病感染早期识别这些口腔表现、提供早期治疗以及降低该感染的高死亡率很重要，但仍需要更多的研究。
