Rajamani Allwyn S, Rammohan Ashwin, Sai Vv Raghavendra, Rela Mohamed
Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai 600036, India.
Institute of Liver Disease and Transplantation, Dr. Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai 600044, India.
World J Hepatol. 2021 Oct 27;13(10):1208-1214. doi: 10.4254/wjh.v13.i10.1208.
Macrovesicular Steatosis (MS) is an independent risk factor for adverse post-liver transplant (LT) outcomes. The degree of MS is intimately related to the viability of the liver graft, which in turn is crucial to the success of the operation. An ideal liver graft should have no MS and most centres would find it unacceptable to use a donor liver with severe MS for LT. While a formal liver biopsy is the gold-standard diagnostic test for MS, given the logistical and time constraints it is not universally feasible. Other tests like a frozen section biopsy are plagued by issues of fallibility with reporting and sampling bias making them inferior to a liver biopsy. Hence, the development of an accurate, non-invasive, easy-to-use, handheld, real-time device for quantification of MS would fill this lacuna in the deceased donor selection process. We present the hypothesis, design and proof-of-concept of a study, which aims to standardise and determine the feasibility and accuracy of a novel handheld device applying the principle of diffuse reflectance spectroscopy for real-time quantification of MS.
大泡性脂肪变性（MS）是肝移植（LT）术后不良结局的独立危险因素。MS的程度与肝移植的生存能力密切相关，而肝移植的生存能力又对手术的成功至关重要。理想的肝移植不应有MS，大多数中心会认为使用严重MS的供体肝脏进行LT是不可接受的。虽然正式的肝活检是MS的金标准诊断测试，但考虑到后勤和时间限制，它并非普遍可行。其他测试，如冰冻切片活检，存在报告易出错和抽样偏差等问题，使其不如肝活检。因此，开发一种准确、无创、易用、手持式、实时的MS定量设备将填补已故供体选择过程中的这一空白。我们提出了一项研究的假设、设计和概念验证，该研究旨在标准化并确定一种新型手持式设备的可行性和准确性，该设备应用漫反射光谱原理对MS进行实时定量。
