Frappaz D, Bouffet E, Biron P, Latour J F, Kassir A, Philip T, Brunat-Mentigny M
Service de pédiatrie, centre Léon-Bérard, Lyon, France.
Pediatrie. 1987;42(4):257-60.
The authors report on a case of methotrexate (MTX) intoxication occurring in a young boy treated for osteosarcoma. Exchange transfusion was shown to be an effective method. Respective indications of MTX removal methods are discussed: haemodialysis and charcoal haemoperfusion should be proposed for massive and acute intoxications; exchange-transfusion may be proposed as a treatment for prolonged and moderate intoxications.
作者报告了一例在接受骨肉瘤治疗的小男孩中发生的甲氨蝶呤（MTX）中毒病例。换血疗法被证明是一种有效的方法。文中讨论了MTX清除方法的各自适应证：对于大量急性中毒应建议进行血液透析和活性炭血液灌流；对于长期中度中毒可建议采用换血疗法作为治疗手段。
