Budtz-Jørgensen E, Milton Knudsen A
Acta Odontol Scand. 1978;36(2):83-7. doi: 10.3109/00016357809027570.
It was the purpose of the study to test the efficacy of brushing with a 1% chlorhexidine gel or a commercial solution cleanser (Steradent) in preventing formation of plaque on the fitting surface of new dentures. The study group consisted of 74 denture wearers with denture stomatitis who were assigned randomly to one of four treatment groups, testing either the chlorhexidine gel, a placebo gel, Steradent, or a placebo solution. The experiment was started immediately after denture treatment was completed. The experimental period was 1 month. The amount of denture plaque, the clinical condition of the palatal mucosa, and the concentration of yeasts in mucosal and denture smears were recorded while the patients used their original dentures and after the experimental period. Plaque had formed on all new dentures but to a smaller extent in the groups testing the chlorhexidine gel or the placebo gel. The study does not provide any obvious evidence of a chemical effect of chlorhexidine gel or Steradent as a means to prevent formation of microbial plaque on the mucosal surface of maxillary complete dentures.
本研究旨在测试使用1%氯己定凝胶或市售溶液清洁剂（Steradent）刷牙对预防新假牙贴合面菌斑形成的效果。研究组由74名患有义齿性口炎的假牙佩戴者组成，他们被随机分配到四个治疗组之一，分别测试氯己定凝胶、安慰剂凝胶、Steradent或安慰剂溶液。在义齿治疗完成后立即开始实验。实验期为1个月。在患者使用其原始假牙时以及实验期结束后，记录假牙菌斑量、腭黏膜的临床状况以及黏膜和假牙涂片上酵母的浓度。所有新假牙上均形成了菌斑，但在测试氯己定凝胶或安慰剂凝胶的组中形成程度较小。该研究没有提供任何明显证据表明氯己定凝胶或Steradent作为预防上颌全口义齿黏膜表面微生物菌斑形成的手段具有化学作用。
