文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

重复经颅磁刺激治疗对帕金森病注意网络的急性改善。

Acute improvement in the attention network with repetitive transcranial magnetic stimulation in Parkinson's disease.

机构信息

Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Department of Neurology, People's Hospital of Deyang City, Deyang, China.

出版信息

Disabil Rehabil. 2022 Dec;44(25):7958-7966. doi: 10.1080/09638288.2021.2004245. Epub 2021 Nov 17.


DOI:10.1080/09638288.2021.2004245
PMID:34787046
Abstract

PURPOSE: To investigate the effect of two weeks of repetitive transcranial magnetic stimulation (rTMS) on the attention network in Parkinson's disease (PD) patients. MATERIALS AND METHODS: Sixty PD patients were randomly divided into equal-sized active- and sham-rTMS groups. Executive function was assessed by neuropsychological tests including the Trail-Making Test (TMT), word fluency test, digit span, Wisconsin Card Sorting Test (WCST) and Stroop test. The attention network was evaluated by the attention network test (ANT). rTMS (5 Hz) was applied over the left dorsolateral prefrontal cortex (DLPFC) in the active-rTMS group, and the sham-rTMS group underwent sham stimulation, both for two weeks. All tests were performed before and after rTMS. RESULTS: After active rTMS, nonparametric analysis revealed significant improvements in categories completed (CC) ( < 0.001) in the WCST and reaction times (RTs) in part 3 ( = 0.002) and the Stroop interference effect (SIE) ( < 0.001) in the Stroop test. Regarding the ANT, the RTs of the executive control network were significantly reduced ( < 0.001). There was no significant change after sham rTMS. CONCLUSIONS: In the short term, in PD patients, rTMS improved the executive control network involved in resolving conflicting information. However, it showed milder effects on neuropsychological test outcomes assessing executive function, which may involve different neuromechanisms.Implications for rehabilitationCognitive impairment is common in patients with Parkinson's disease (PD), and it is related to functional disability and reduced quality of life.Attention is a main component of the cognitive system, and attention deficits are responsible for disability.This study demonstrates that rTMS is beneficial for cognitive rehabilitation in PD, as patients showed improved performance on the attention network test and neuropsychological tests.

摘要

目的:探讨重复经颅磁刺激(rTMS)对帕金森病(PD)患者注意网络的影响。

材料与方法:将 60 例 PD 患者随机均分为真刺激组和假刺激组。采用神经心理学测试,包括连线测试(TMT)、词语流畅性测试、数字跨度、威斯康星卡片分类测试(WCST)和斯特鲁普测试,评估执行功能。采用注意网络测试(ANT)评估注意网络。在真刺激组中,将 rTMS(5Hz)应用于左侧背外侧前额叶皮质(DLPFC),假刺激组进行假刺激,均持续 2 周。所有测试在 rTMS 前后进行。

结果:在真刺激 rTMS 后,非参数分析显示 WCST 的完成分类数(CC)( < 0.001)和 WCST 第三部分的反应时(RT)( = 0.002)以及斯特鲁普干扰效应(SIE)( < 0.001)均有显著改善。在 ANT 方面,执行控制网络的 RT 明显降低( < 0.001)。假刺激 rTMS 后无显著变化。

结论:在短期治疗中,rTMS 可改善参与处理冲突信息的执行控制网络,对评估执行功能的神经心理学测试结果的影响较小,这可能涉及不同的神经机制。

康复意义:认知障碍在帕金森病(PD)患者中很常见,与功能障碍和生活质量下降有关。注意是认知系统的主要组成部分,注意缺陷是导致残疾的原因。本研究表明,rTMS 对 PD 的认知康复有益,因为患者在注意力网络测试和神经心理学测试中的表现均有所改善。

相似文献

[1]
Acute improvement in the attention network with repetitive transcranial magnetic stimulation in Parkinson's disease.

Disabil Rehabil. 2022-12

[2]
The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease: a randomized, double-blind, placebo-controlled study.

Mov Disord. 2010-10-30

[3]
Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex affects divided attention immediately after cessation of stimulation.

J Psychiatr Res. 2006-6

[4]
Effect of high frequency repetitive transcranial magnetic stimulation on reaction time, clinical features and cognitive functions in patients with Parkinson's disease.

J Neural Transm (Vienna). 2009-9

[5]
Cognitive Effects of High-Frequency rTMS in Schizophrenia Patients With Predominant Negative Symptoms: Results From a Multicenter Randomized Sham-Controlled Trial.

Schizophr Bull. 2016-5

[6]
Effects of repetitive transcranial magnetic stimulation over right dorsolateral prefrontal cortex on excessive daytime sleepiness in patients with Parkinson's disease.

Sleep Med. 2022-12

[7]
Effect of rTMS on Parkinson's cognitive function: a systematic review and meta-analysis.

BMC Neurol. 2020-10-19

[8]
Repetitive transcranial magnetic stimulation in combination with citalopram in young patients with first-episode major depressive disorder: a double-blind, randomized, sham-controlled trial.

Aust N Z J Psychiatry. 2012-1-5

[9]
Integration of Virtual Reality into Transcranial Magnetic Stimulation Improves Cognitive Function in Patients with Parkinson's Disease with Cognitive Impairment: A Proof-of-Concept Study.

J Parkinsons Dis. 2022

[10]
Follow up study: The influence of rTMS with high and low frequency stimulation on motor and executive function in Parkinson's disease.

Brain Res Bull. 2017-10-5

引用本文的文献

[1]
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Reduces Variability in Brain Function in Schizophrenia: Data From a Double-Blind, Randomized, Sham-Controlled Trial.

Schizophr Bull. 2025-5-8

[2]
TMS and tDCS as potential tools for the treatment of cognitive deficits in Parkinson's disease: a meta-analysis.

Neurol Sci. 2025-2

[3]
Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.

Clin Neurophysiol. 2024-8

[4]
Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis.

Int Psychogeriatr. 2024-10

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索