Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.
Department of Medical Humanities and Social Sciences, Yonsei University College of Medicine, Seoul, South Korea.
Expert Rev Vaccines. 2022 Jan;21(1):91-101. doi: 10.1080/14760584.2022.2008246. Epub 2021 Nov 26.
Mucosal vaccines have several advantages over parenteral vaccines. They induce both systemic and mucosal antigen-specific immune responses, allow easy administration, and bypass the need for trained medical personnel.
Eye mucosa is a novel route of mucosal vaccine administration. Eyedrop vaccination induces systemic and mucosal immune responses similar to other forms of mucosal vaccines such as oral and intranasal vaccines.
Eyedrop vaccines are free of serious adverse side effects like the infiltration of CNS by pathogens. Studies over the years have shown promising results for eye drop vaccines against infectious agents like the influenza virus, and in animal models. Such efficacy and safety of eyedrop vaccination enable the application of eyedrop vaccines against other infectious diseases as well as chronic diseases. In this review of published literature, we examine the mechanism, efficacy, and safety of eyedrop vaccines and contemplate their role in times of a pandemic.
黏膜疫苗相对于注射疫苗具有多种优势。它们可以诱导系统和黏膜抗原特异性免疫应答，易于给药，并且不需要经过培训的医务人员。
眼部黏膜是黏膜疫苗给药的一种新途径。滴眼疫苗可诱导与其他形式的黏膜疫苗（如口服和鼻内疫苗）相似的全身和黏膜免疫应答。
滴眼疫苗没有严重的不良副作用，例如病原体渗透到中枢神经系统。多年的研究表明，滴眼疫苗在动物模型中对抗流感病毒等传染性病原体具有有前景的效果。这种滴眼疫苗的功效和安全性使滴眼疫苗能够应用于其他传染病和慢性病。在对已发表文献的综述中，我们研究了滴眼疫苗的机制、功效和安全性，并思考了它们在大流行期间的作用。
