Department of Mechanical Engineering, Imam Reza University of Applied Science and Technology, Kermanshah, Iran.
School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai, Malaysia.
J Biomed Mater Res B Appl Biomater. 2022 Apr;110(4):838-847. doi: 10.1002/jbm.b.34964. Epub 2021 Nov 17.
The unique characteristics of polyether ether ketone (PEEK) including low elastic modulus, high mechanical strength, and biocompatibility have made it an attractive alternative for the metallic biomaterials. However, its bioinert property is always the main concern, which could lead to poor osseointegration and subsequent clinical failure of the implant. Changing the surface structure to porous structure and mixing it with bioactive hydroxyapatite (HA) are the common methods, which could be used to enhance the properties of the PEEK-based implants. In this study, friction stir processing was utilized for the fabrication of porous HA/PEEK surface nanocomposite. Scanning electron microscopic image of the nanocomposite surface showed nano-scale roughness of the porous structure. Water contact angle test confirmed the increase in the wettability of the treated specimens. In vitro bioactivity test via simulated body fluid solution, initial cell adhesion, cell proliferation, and cell differentiation assay also confirmed the enhancement in bioactivity of the treated surface in comparison to the bare PEEK. This surface modification method requires no special equipment and would not damage the heat-sensitive PEEK substrate due to the low temperature used during the fabrication process.
聚醚醚酮（PEEK）具有独特的特性，包括低弹性模量、高机械强度和生物相容性，使其成为金属生物材料的一种有吸引力的替代品。然而，其生物惰性一直是主要关注点，这可能导致植入物的骨整合不良和随后的临床失败。改变表面结构为多孔结构并将其与生物活性羟基磷灰石（HA）混合是常用的方法，可用于增强基于 PEEK 的植入物的性能。在这项研究中，利用摩擦搅拌加工制备了多孔 HA/PEEK 表面纳米复合材料。纳米复合材料表面的扫描电子显微镜图像显示出多孔结构的纳米级粗糙度。水接触角测试证实了处理后的样品润湿性的增加。通过模拟体液溶液进行的体外生物活性测试、初始细胞黏附、细胞增殖和细胞分化试验也证实，与裸 PEEK 相比，处理表面的生物活性得到了增强。这种表面改性方法不需要特殊设备，并且由于制造过程中使用的低温不会损坏对热敏感的 PEEK 基底。
