利用丹麦 COVID-19 疫情期间对献血者进行的抗体筛查，按年龄和合并症状况估算 SARS-CoV-2 感染病死率。
Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors During the COVID-19 Epidemic in Denmark.
机构信息
Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Danish Big Data Centre for Environment and Health, Aarhus University, Roskilde, Denmark.
出版信息
J Infect Dis. 2022 Jan 18;225(2):219-228. doi: 10.1093/infdis/jiab566.
BACKGROUND
Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality.
METHODS
Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark.
RESULTS
In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave.
CONCLUSIONS
In this nationwide study, the IFR was very low among people <51 years without comorbidity.
背景
有必要针对健康个体的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染病死率（IFR）进行研究。我们利用丹麦献血者大型血清学调查数据和 2019 冠状病毒病（COVID-19）死亡率的全国性数据，按年龄和合并症状况估算 IFR。
方法
2020 年 10 月至 2021 年 2 月期间，年龄在 17-69 岁的丹麦献血者捐献血液，采用商业 SARS-CoV-2 总抗体检测试剂进行检测。IFR 是在 2020 年第 11 周至第 42 周和 2021 年第 43 周至第 6 周期间估算的，代表了 COVID-19 在丹麦的前 2 波流行。
结果
共检测了 84944 名献血者的抗体。2020 年 10 月的血清阳性率为 2%，2021 年 2 月为 7%。在年龄为 17-69 岁的 3898039 名丹麦居民中，记录到 249 例死亡。在第 1 和第 2 波中，无合并症的年龄<51 岁人群的 IFR 较低（合并 IFR=每 100000 例感染 3.36 例）。无合并症的 61-69 岁人群的 IFR 低于 3/1000。IFR 随年龄和合并症的增加而升高，但从第 1 波到第 2 波下降。
结论
在这项全国性研究中，无合并症的年龄<51 岁人群的 IFR 非常低。
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