Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Int J Med Sci. 2021 Oct 16;18(16):3794-3799. doi: 10.7150/ijms.61973. eCollection 2021.
Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. IFN regulatory factors (IRFs) function in both innate and adaptive immune responses, and their effect is associated with the regulation of type I IFNs. In this review, we focus on recent advances in understanding the expression of TLRs, IRFs, and type I IFNs in psoriasis. We also highlight the interplay among TLRs, IRFs, and type I IFNs.
银屑病是一种慢性炎症性疾病，涉及固有免疫和适应性免疫系统。I 型干扰素（IFNs）的产生部分受 Toll 样受体（TLRs）调控，在银屑病发病机制中发挥重要作用，特别是在皮肤创伤引起的银屑病中，称为 Koebner 现象。干扰素调节因子（IRFs）在固有免疫和适应性免疫反应中发挥作用，其作用与 I 型 IFNs 的调节有关。在这篇综述中，我们重点介绍了在理解银屑病中 TLRs、IRFs 和 I 型 IFNs 的表达方面的最新进展。我们还强调了 TLRs、IRFs 和 I 型 IFNs 之间的相互作用。
