Dong Xue, Jiang Hong, Li Suyun, Zhang Dongfeng
Department of Epidemiology and Health Statistics, The School of Public Health, Qingdao University, Qingdao, China.
Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Department of Physiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Front Aging Neurosci. 2021 Nov 1;13:712237. doi: 10.3389/fnagi.2021.712237. eCollection 2021.
Current evidence on the association between serum testosterone and cognitive performance has been inconsistent, especially in older adults. To investigate the associations between serum testosterone and cognitive performance in a nationally representative sample of older men and women. We used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. 1,303 men and 1,349 women aged 60 years or older were included in the study. Serum total testosterone was preformed via isotope dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) method. Free testosterone was calculated by Vermeulen's formula. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). Binary logistic regression and restricted cubic spline models were applied to evaluate the association of testosterone and cognitive performance. In men, higher concentrations of total testosterone were associated with better performance on CERAD test (OR = 0.51; 95%CI = 0.27-0.95) and DSST (OR = 0.54; 95%CI = 0.30-0.99) in adjusted group. Similarly, higher concentrations of free testosterone were associated with better performance on CERAD test (OR = 0.32; 95%CI = 0.17-0.61) and DSST (OR = 0.41; 95%CI = 0.17-0.96) in men. These associations were not seen in women. Serum testosterone concentrations were inversely associated with cognitive performance in older men but not women in the United States.
目前关于血清睾酮与认知功能之间关联的证据并不一致，尤其是在老年人中。为了在具有全国代表性的老年男性和女性样本中研究血清睾酮与认知功能之间的关联。我们使用了2011 - 2014年国家健康与营养检查调查（NHANES）的数据。该研究纳入了1303名60岁及以上的男性和1349名60岁及以上的女性。血清总睾酮通过同位素稀释液相色谱串联质谱法（ID - LC - MS/MS）测定。游离睾酮通过韦尔梅伦公式计算。认知功能通过阿尔茨海默病注册协会（CERAD）测试、动物流畅性测试和数字符号替换测试（DSST）进行评估。应用二元逻辑回归和受限立方样条模型来评估睾酮与认知功能之间的关联。在男性中，调整组中总睾酮浓度较高与CERAD测试（OR = 0.51；95%CI = 0.27 - 0.95）和DSST（OR = 0.54；95%CI = 0.30 - 0.99）表现更好相关。同样，在男性中，游离睾酮浓度较高与CERAD测试（OR = 0.32；95%CI = 0.17 - 0.61）和DSST（OR = 0.41；95%CI = 0.17 - 0.96）表现更好相关。在女性中未观察到这些关联。在美国，老年男性的血清睾酮浓度与认知功能呈负相关，而老年女性则不然。
