ω-3 和 ω-6 脂肪酸摄入与老年人认知表现的关联：2011-2014 年国家健康与营养调查（NHANES）。
Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011-2014.
机构信息
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, 38 Deng Zhou Street, Qingdao, 266021, Shandong Province, China.
出版信息
Nutr J. 2020 Mar 28;19(1):25. doi: 10.1186/s12937-020-00547-7.
BACKGROUND
Current evidence on the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance is inconsistent. Therefore, the aim is to explore the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in the U.S. noninstitutionalized population of older adults.
METHODS
We used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Intakes of ω-3 and ω-6 fatty acids were obtained through two 24-h dietary recalls and were adjusted by energy. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's disease (CERAD) Word Learning sub-test, Animal Fluency test and Digit Symbol Substitution Test (DSST). For each cognitive test, people who scored lower than the lowest quartile in each age group were defined as having low cognitive performance. Binary logistic regression and restricted cubic spline models were applied to evaluate the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance.
RESULTS
A total of 2496 participants aged 60 years or older were included. In the full-adjusted model, the odds ratios (ORs) with 95% confidence interval (CI) of CERAD test score, Animal Fluency test score and DSST test score were 0.58 (0.38-0.88), 0.68 (0.47-0.99) and 0.59 (0.37-0.92) for the highest versus lowest tertile of dietary ω-3 fatty acids intake, respectively; the ORs with 95% CI of CERAD test score, Animal Fluency test score and DSST test score were 0.48 (0.31-0.75), 0.60 (0.40-0.92) and 0.50 (0.34-0.75) for the highest versus lowest tertile of dietary ω-6 fatty acids intake, respectively. The association between ω-6: ω-3 ratio and cognitive performance was not statistically significant in three tests. In dose-response relationship analysis, L-shaped associations were apparent for ω-3 and ω-6 fatty acids intake with CERAD test score, Animal Fluency test score and DSST test score.
CONCLUSIONS
Dietary ω-3 and ω-6 fatty acids intake might be inversely associated with low cognitive performance.
背景
目前关于饮食 ω-3 和 ω-6 脂肪酸摄入与认知表现之间关联的证据并不一致。因此，本研究旨在探讨美国非机构化老年人群中饮食 ω-3 和 ω-6 脂肪酸摄入与认知表现之间的关系。
方法
我们使用了 2011-2014 年全国健康和营养调查（NHANES）的数据。通过两次 24 小时膳食回忆获取 ω-3 和 ω-6 脂肪酸的摄入量，并按能量进行调整。认知表现通过认知障碍建立协会（CERAD）单词学习子测验、动物流畅性测验和数字符号替代测验（DSST）进行评估。对于每项认知测试，每个年龄组中得分低于最低四分位数的人被定义为认知表现较低。应用二项逻辑回归和限制三次样条模型评估饮食 ω-3 和 ω-6 脂肪酸摄入与认知表现之间的关系。
结果
共纳入 2496 名 60 岁及以上的参与者。在全调整模型中，与饮食 ω-3 脂肪酸摄入最高三分位相比，最低三分位的 CERAD 测试评分、动物流畅性测试评分和 DSST 测试评分的比值比（OR）及其 95%置信区间（CI）分别为 0.58（0.38-0.88）、0.68（0.47-0.99）和 0.59（0.37-0.92）；与饮食 ω-6 脂肪酸摄入最高三分位相比，最低三分位的 CERAD 测试评分、动物流畅性测试评分和 DSST 测试评分的 OR 及其 95%CI 分别为 0.48（0.31-0.75）、0.60（0.40-0.92）和 0.50（0.34-0.75）。在三项测试中，ω-6:ω-3 比值与认知表现之间的关联均无统计学意义。在剂量-反应关系分析中，ω-3 和 ω-6 脂肪酸摄入与 CERAD 测试评分、动物流畅性测试评分和 DSST 测试评分呈 L 型关联。
结论
饮食 ω-3 和 ω-6 脂肪酸的摄入可能与认知表现较低呈负相关。
Zotero 插件