抗癫痫药物联合使用导致的心脏钠通道阻滞
Cardiac Sodium Channel Blockade Due to Antiepileptic Drug Combination.
作者信息
Maadarani Ossama, Bitar Zouheir, Ashkanani Abdelaziz, Elzoueiry Mahmoud, Elhabibi Mohamad, Gohar Mohamad, Almuwaizri Mohamad, Shoeb Sania, Alsaddah Jadan
机构信息
Internal Medicine Department, Ahmadi Hospital, Kuwait Oil Company, Al Ahmadi, Kuwait.
Nursing Department, Ahmadi Hospital, Kuwait Oil Company, Al Ahmadi, Kuwait.
出版信息
Eur J Case Rep Intern Med. 2021 Oct 4;8(10):002839. doi: 10.12890/2021_002839. eCollection 2021.
UNLABELLED
Drugs that inhibit voltage-dependent sodium channels are commonly used to treat epilepsy. Old and novel antiepileptic drugs are used either as monotherapy or in combination to control epilepsy. For a long time, carbamazepine has been used as the first choice for the treatment of simple and complex partial seizures. In the USA, lacosamide was approved in October 2008 as an adjunctive treatment for partial-onset seizures. We describe the effect of two sodium channel blockers on the heart of a patient with epilepsy.
LEARNING POINTS
Approximately 30% of patients with epilepsy require combination therapy with antiepileptic drugs for seizure reduction.Lacosamide and carbamazepine are both sodium channel blockers but exert their effects through different mechanisms.Electrocardiogram monitoring is necessary when lacosamide and carbamazepine are used together as this combination may predispose to seizures, conduction abnormalities and dysrhythmia.
未标注
抑制电压依赖性钠通道的药物常用于治疗癫痫。新旧抗癫痫药物可单独使用或联合使用以控制癫痫。长期以来，卡马西平一直被用作治疗单纯性和复杂性部分性发作的首选药物。2008年10月，拉科酰胺在美国被批准作为部分性发作的辅助治疗药物。我们描述了两种钠通道阻滞剂对一名癫痫患者心脏的影响。
学习要点
约30%的癫痫患者需要联合使用抗癫痫药物以减少发作。拉科酰胺和卡马西平都是钠通道阻滞剂，但作用机制不同。当拉科酰胺和卡马西平联合使用时，有必要进行心电图监测，因为这种联合用药可能易引发癫痫、传导异常和心律失常。
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