Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, Prague, 16610, Czech Republic.
J Phys Chem B. 2022 Jan 20;126(2):355-367. doi: 10.1021/acs.jpcb.1c08370. Epub 2021 Nov 18.
Resonance Raman Optical Activity (RROA) appeared as a natural extension of the nonresonance branch. It combines the structural sensitivity of chiroptical spectroscopy with the signal enhancement coming from the resonance of molecular electronic transitions with the excitation laser light. However, the idea has been hampered by many technical and theoretical problems that are being clarified only in recent years. We provide the theoretical basis and several examples documenting the problems, achievements, and potential of RROA, in particular in biomolecular studies.
共振拉曼光学活性（RROA）似乎是无共振分支的自然延伸。它将手性光谱学的结构敏感性与分子电子跃迁与激发激光光的共振所带来的信号增强相结合。然而，这个想法受到了许多技术和理论问题的阻碍，这些问题直到近年来才得到澄清。我们提供了 RROA 的理论基础和几个例子，这些例子记录了 RROA 在生物分子研究中的问题、成就和潜力。
