Section of Clinical and Health Psychology, School of Health in Social Science, University of Edinburgh, Edinburgh, UK.
Psychology Department, Royal Edinburgh Hospital, NHS Lothian, Edinburgh, UK.
Clin Psychol Psychother. 2022 May;29(3):1068-1079. doi: 10.1002/cpp.2692. Epub 2021 Dec 17.
Although patients often prioritize the treatment of negative symptoms, few psychological interventions targeting negative symptoms exist. This study attempts to fill this gap by piloting a modified metacognitive training programme, specifically targeted at negative symptoms (MCT-N), with a group of patients with prominent negative symptoms.
We adopted a mixed methods case series design, providing detailed quantitative data on changes over time, to focus on potential mechanisms underlying the intervention, in combination with qualitative interviews.
The intervention showed good feasibility as demonstrated by the attendance rate, the positive feedback from participants and the multidisciplinary team, and the improvements on negative symptoms observed following the intervention. Multilevel modelling showed that depression, internalized stigma and reflective functioning explained the variance in negative symptoms.
The pilot study indicated that the intervention has high feasibility and that improvements in negative symptoms can be partially explained by improvements on depression, stigma and reflective functioning.
尽管患者常优先考虑负面症状的治疗，但针对负面症状的心理干预措施却寥寥无几。本研究试图通过对一组有明显负面症状的患者进行改良的元认知训练方案（MCT-N）来填补这一空白，该方案专门针对负面症状。
我们采用混合方法病例系列设计，提供了随时间变化的详细定量数据，以关注干预背后的潜在机制，并结合定性访谈。
该干预措施的出勤率高，参与者和多学科团队的反馈积极，干预后负面症状得到改善，表明其具有良好的可行性。多层次模型显示，抑郁、内化污名和反思功能解释了负面症状的差异。
初步研究表明，该干预措施具有很高的可行性，负面症状的改善可以部分归因于抑郁、污名和反思功能的改善。
