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[利用单克隆抗体检测人类白血病的红系变体]

[Determination of erythroid variants of human leukemias using monoclonal antibodies].

作者信息

Tupitsyn N N, Mechetner E B, Baryshnikov A Iu, Rozinova E N

出版信息

Eksp Onkol. 1987;9(4):30-4.

PMID:3479320
Abstract

Expression of erythroid antigens identifying with the use of monoclonal antibodies (mab) HAE3 and HAE9 was studied in 333 patients with different types of hemoblastoses. Frequency of erythroid variants based on the reaction with mab was 5.7%. In 2.4% of cases erythroid markers were the only indication on the nature of leukemia. In 2.7% of cases the types of leukemia were accounted for as "mixed" ones, i.e. erythrolymphoid and erythromyeloid variants. Only in 0.6% of cases erythroid variant was detected by the morphological criteria.

摘要

使用单克隆抗体(mab)HAE3和HAE9对333例不同类型成血病患者的红细胞抗原表达进行了研究。基于与单克隆抗体反应的红细胞变体频率为5.7%。在2.4%的病例中,红细胞标志物是白血病性质的唯一指征。在2.7%的病例中,白血病类型被归为“混合”类型,即红细胞淋巴细胞和红细胞髓细胞变体。仅在0.6%的病例中通过形态学标准检测到红细胞变体。

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