Department of Chemistry, University of Bergen, Bergen, Norway.
Førde Health Trust, Førde, Norway.
PLoS One. 2021 Nov 18;16(11):e0259901. doi: 10.1371/journal.pone.0259901. eCollection 2021.
Aerobic fitness (AF) and lipoprotein subclasses associate to each other and to cardiovascular health. Adiposity and physical activity (PA) influence the association pattern of AF to lipoproteins almost inversely making it difficult to assess their independent and joint influence on the association pattern. This study, including 841 children (50% boys) 10.2 ± 0.3 years old with BMI 18.0 ± 3.0 kg/m2 from rural Western Norway, aimed at examining the association pattern of AF to the lipoprotein subclasses and to estimate the independent and joint influence of PA and adiposity on this pattern. We used multivariate analysis to determine the association pattern of a profile of 26 lipoprotein features to AF with and without adjustment for three measures of adiposity and a high-resolution PA descriptor of 23 intensity intervals derived from accelerometry. For data not adjusted for adiposity or PA, we observed a cardioprotective lipoprotein pattern associating to AF. This pattern withstood adjustment for PA, but the strength of association to AF was reduced by 58%, while adjustment for adiposity weakened the association of AF to the lipoproteins by 85% and with strongest changes in the associations to a cardioprotective high-density lipoprotein subclass pattern. When adjusted for both adiposity and PA, the cardioprotective lipoprotein pattern still associated to AF, but the strength of association was reduced by 90%. Our results imply that the (negative) influence of adiposity on the cardioprotective association pattern of lipoproteins to AF is considerably stronger than the (positive) contribution of PA to this pattern. However, our analysis shows that PA contributes also indirectly through a strong inverse association to adiposity. The trial was registered 7 May, 2014 in clinicaltrials.gov with trial reg. no.: NCT02132494 and the URL is https://clinicaltrials.gov/ct2/results?term=NCT02132494&cntry=NO.
有氧适能（AF）和脂蛋白亚类相互关联，并与心血管健康相关。肥胖和体力活动（PA）几乎相反地影响 AF 与脂蛋白的关联模式，使得难以评估它们对关联模式的独立和联合影响。本研究包括来自挪威西部农村的 841 名儿童（50%为男孩），年龄为 10.2 ± 0.3 岁，BMI 为 18.0 ± 3.0 kg/m2，旨在检查 AF 与脂蛋白亚类的关联模式，并估计 PA 和肥胖对该模式的独立和联合影响。我们使用多元分析来确定 26 种脂蛋白特征的特征与 AF 的关联模式，同时调整了三种肥胖测量值和加速度计得出的 23 个强度间隔的高分辨率 PA 描述符。对于未调整肥胖或 PA 的数据，我们观察到与 AF 相关的保护性脂蛋白模式。这种模式在调整 PA 后仍然存在，但与 AF 的关联强度降低了 58%，而调整肥胖则使 AF 与脂蛋白的关联减弱了 85%，对保护性高密度脂蛋白亚类模式的关联变化最大。当同时调整肥胖和 PA 时，保护性脂蛋白模式仍与 AF 相关，但关联强度降低了 90%。我们的结果表明，肥胖对 AF 与脂蛋白的保护性关联模式的（负面）影响远远强于 PA 对该模式的（积极）贡献。然而，我们的分析表明，PA 也通过与肥胖的强烈负相关间接贡献。该试验于 2014 年 5 月 7 日在 clinicaltrials.gov 上注册，试验注册号为 NCT02132494，网址为 https://clinicaltrials.gov/ct2/results?term=NCT02132494&cntry=NO。
