Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Department of Chemistry, University of Bergen, Bergen, Norway; Førde Health Trust, Førde, Norway.
Atherosclerosis. 2021 Mar;321:21-29. doi: 10.1016/j.atherosclerosis.2021.02.002. Epub 2021 Feb 8.
The associations between aerobic fitness and traditional measures of lipid metabolism in children are uncertain. We investigated whether higher levels of aerobic fitness benefit lipoprotein metabolism by exploring associations with a comprehensive lipoprotein particle profile.
In our prospective cohort study, we used targeted proton nuclear magnetic resonance (H NMR) spectroscopy to profile 57 measures of lipoprotein metabolism from fasting serum samples of 858 fifth-grade Norwegian schoolchildren (49.0% girls; mean age 10.0 years). Aerobic fitness was measured using an intermittent shuttle run aerobic fitness test. We used multiple linear regression adjusted for potential confounders to examine cross-sectional and prospective associations between aerobic fitness and lipoprotein particle profile.
Higher levels of aerobic fitness were associated with a favourable lipoprotein particle profile in the cross-sectional analysis, which included inverse associations with all measures of very low-density lipoprotein (VLDL) particles (e.g., -0.06 mmol·L or -0.23 SD units; 95% CI = -0.31, -0.16 for VLDL cholesterol concentration). In the prospective analysis, the favourable pattern of associations persisted, though the individual associations tended to be more consistent with those of the cross-sectional analysis for the VLDL subclass measures compared to the low-density lipoproteins and high-density lipoproteins. Adjustment for adiposity attenuated the associations in both cross-sectional and prospective models. Nevertheless, an independent effect of aerobic fitness remained for some measures.
Improving children's aerobic fitness levels should benefit lipoprotein metabolism, though a concomitant reduction in adiposity would likely potentiate this effect.
儿童有氧健身与传统脂代谢指标之间的关联尚不确定。我们通过探索与综合脂蛋白颗粒谱的关联，研究了更高水平的有氧健身是否有益于脂蛋白代谢。
在我们的前瞻性队列研究中，我们使用靶向质子核磁共振（H NMR）光谱法对 858 名挪威五年级小学生空腹血清样本中的 57 种脂蛋白代谢指标进行了分析（49.0%为女生；平均年龄 10.0 岁）。采用间歇性穿梭跑有氧健身测试来测量有氧健身能力。我们使用多元线性回归来调整潜在的混杂因素，以检验有氧健身能力与脂蛋白颗粒谱之间的横断面和前瞻性关联。
在横断面分析中，较高的有氧健身水平与有利的脂蛋白颗粒谱相关，其中包括与所有极低密度脂蛋白（VLDL）颗粒的指标呈负相关（例如，-0.06 mmol·L 或 -0.23 SD 单位；95%CI = -0.31，-0.16 为 VLDL 胆固醇浓度）。在前瞻性分析中，这种有利的关联模式仍然存在，尽管与 LDL 和 HDL 相比，VLDL 亚类指标的个体关联更符合横断面分析的结果。在横断面和前瞻性模型中，肥胖调整均减弱了关联。尽管如此，有氧健身能力的独立影响仍然存在于某些指标中。
提高儿童的有氧健身水平应该有益于脂蛋白代谢，尽管伴随的肥胖减少可能会增强这种效果。
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