Division of Gastroenterology and Hepatology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.
Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan.
PLoS One. 2021 Nov 18;16(11):e0260012. doi: 10.1371/journal.pone.0260012. eCollection 2021.
Study of inflammatory cytokines in patients with caustic gastrointestinal tract injury is sketchy. This study investigated the cytokine profiling of patients with caustic substance ingestion, and analyzed the differences between patients with severe and mild injury.
This prospective, cross-sectional study enrolled 22 patients admitted to Chang Gung Memorial Hospital between March and October 2018. All patients underwent esophagogastroduodenoscopy in 24 hours. Patients were categorized into two subgroups, as mild (<2b, n = 11) or severe (≥2b, n = 11) group.
The neutrophil count was higher in severe than mild group (P = 0.032). Patients in mild and severe groups exhibited significantly higher circulating inflammatory cytokines than healthy control, including interleukin (IL)-2, IL-5, IL-8, IL-9, IL-12, IL-13, interferon-gamma inducible protein-10, macrophage inflammatory protein-1 beta, regulated upon activation, normal T cell expressed and presumably secreted and tumor necrosis factor-alpha. Furthermore, the levels of IL-2 and tumor necrosis factor-alpha were significantly higher in patients with severe group than mild group. Although there was no difference in cumulative survival between both groups (P = 0.147), the severe group received more operations (P = 0.035) and suffered more gastrointestinal complications (P = 0.035) than mild group.
Caustic substance ingestion produces mucosal damages and leads to excessive neutrophils and inflammatory cytokines in peripheral blood.
研究腐蚀性胃肠道损伤患者的炎症细胞因子的资料有限。本研究调查了腐蚀性物质摄入患者的细胞因子谱，并分析了严重和轻度损伤患者之间的差异。
本前瞻性、横断面研究纳入了 2018 年 3 月至 10 月期间在长庚纪念医院住院的 22 名患者。所有患者均在 24 小时内行食管胃十二指肠镜检查。患者分为轻度（<2b，n=11）或重度（≥2b，n=11）组。
重度组中性粒细胞计数高于轻度组（P=0.032）。轻度和重度组患者的循环炎症细胞因子明显高于健康对照组，包括白细胞介素（IL）-2、IL-5、IL-8、IL-9、IL-12、IL-13、干扰素-γ诱导蛋白-10、巨噬细胞炎症蛋白-1β、活化调节正常 T 细胞表达和分泌和肿瘤坏死因子-α。此外，重度组患者的 IL-2 和肿瘤坏死因子-α水平明显高于轻度组。尽管两组之间的累积生存率无差异（P=0.147），但重度组接受了更多的手术（P=0.035），且胃肠道并发症更多（P=0.035）。
腐蚀性物质摄入会导致黏膜损伤，并导致外周血中过多的中性粒细胞和炎症细胞因子。
