Lenze Nicholas R, Bensen Jeannette T, Farnan Laura, Sheth Siddharth, Zevallos Jose P, Yarbrough Wendell G, Zanation Adam M
Department of Otolaryngology - Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Department of Otolaryngology-Head & Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Head Neck. 2022 Feb;44(2):412-419. doi: 10.1002/hed.26934. Epub 2021 Nov 18.
There is a paucity of data on financial toxicity among patients with head and neck squamous cell carcinoma (HNSCC).
This was a retrospective, cross-sectional study of patients with HNSCC surveyed at an outpatient oncology clinic.
The sample included 202 patients with HNSCC with a mean age of 59.6 years (SD 10.0). There were 53 patients (26%) with self-reported financial burden. Education of high school or less was a significant predictor of self-reported financial burden (OR 2.52, 95% CI 1.03-6.14, p = 0.042). Patients reporting financial burden had significantly worse physical (p = 0.003), mental (p = 0.003), and functional (p = 0.036) health-related quality of life (HRQOL). Patients reporting financial burden appeared to have lower 5-year overall survival (74.3% vs. 83.9%, p = 0.165), but this association did not reach statistical significance.
Financial burden or toxicity may affect approximately a quarter of patients with HNSCC and appears to be associated with worse HRQOL outcomes.
头颈部鳞状细胞癌（HNSCC）患者中关于经济毒性的数据匮乏。
这是一项对在门诊肿瘤诊所接受调查的HNSCC患者进行的回顾性横断面研究。
样本包括202例HNSCC患者，平均年龄59.6岁（标准差10.0）。有53例患者（26%）自我报告有经济负担。高中及以下学历是自我报告经济负担的显著预测因素（比值比2.52，95%置信区间1.03 - 6.14，p = 0.042）。报告有经济负担的患者在身体（p = 0.003）、心理（p = 0.003）和功能（p = 0.036）方面与健康相关的生活质量（HRQOL）明显更差。报告有经济负担的患者5年总生存率似乎较低（74.3%对83.9%，p = 0.165），但这种关联未达到统计学显著性。
经济负担或毒性可能影响约四分之一的HNSCC患者，并且似乎与更差的HRQOL结果相关。
