Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
Vet Ophthalmol. 2022 May;25 Suppl 1:111-121. doi: 10.1111/vop.12955. Epub 2021 Nov 18.
To evaluate the clinical application of spectral-domain optical coherence tomography (SD-OCT) for anterior uveitis in dogs. Animals and procedures Client-owned dogs presenting with anterior uveitis and clinically healthy dogs were enrolled in this study. Included eyes were divided into 5 groups by flare grade and 3 groups by cell grade through slit-lamp biomicroscopy. Each eye was examined using SD-OCT following slit-lamp biomicroscopy. The ratio of aqueous signal intensity to air signal intensity, which is called the aqueous-to-air relative intensity (ARI) index, was used to evaluate the flare grade. Cell number, central corneal thickness (CCT), and the presence of keratic precipitates (KPs) were analyzed on SD-OCT. The OCT parameters, including ARI index, cell number, and CCT, were compared to the slit-lamp clinical flare and cell grade.
Thirty-six eyes with anterior uveitis and 27 healthy eyes were enrolled. The ARI index showed a significant correlation with clinical flare grade (r = 0.811, p < .001). In multiple regression analysis, the ARI index and CCT showed a significant negative correlation (r = -0.258, p = .044). The number of cells on SD-OCT significantly increased with cell grade on slit-lamp biomicroscopy (r = 0.653, p < .001). The clinical flare grade and CCT were significantly correlated in the partial correlation analysis after controlling for age (partial correlation coefficient = 0.471, p = .002). KPs were observed in 61% of the eyes with flare using SD-OCT (22/36 eyes).
Spectral-domain optical coherence tomography could provide quantitative information, including the ARI index, cell counts, and CCT in dogs. SD-OCT is an auxiliary modality for slit-lamp biomicroscopy when evaluating anterior uveitis in dogs.
评估频域光相干断层扫描（SD-OCT）在犬前葡萄膜炎中的临床应用。
本研究纳入了患有前葡萄膜炎的患宠犬和临床健康的犬。通过裂隙灯生物显微镜将纳入的眼睛分为 5 个 flare 级别的组和 3 个细胞级别的组。在裂隙灯生物显微镜检查后，使用 SD-OCT 检查每只眼睛。通过评估水信号强度与空气信号强度的比值，即所谓的水到空气相对强度（ARI）指数，来评估 flare 级。通过 SD-OCT 分析细胞数量、中央角膜厚度（CCT）和角膜后沉着物（KPs）的存在。比较 OCT 参数，包括 ARI 指数、细胞数量和 CCT，与裂隙灯临床 flare 和细胞分级。
纳入了 36 只患有前葡萄膜炎的眼睛和 27 只健康的眼睛。ARI 指数与临床 flare 分级呈显著相关性（r = 0.811，p < .001）。在多元回归分析中，ARI 指数和 CCT 呈显著负相关（r = -0.258，p = .044）。SD-OCT 上的细胞数量随着裂隙灯生物显微镜上的细胞分级显著增加（r = 0.653，p < .001）。在控制年龄的偏相关分析中，临床 flare 分级和 CCT 显著相关（偏相关系数=0.471，p = .002）。SD-OCT 检测到 61%的 flare 眼睛有 KPs（22/36 眼）。
SD-OCT 可为犬前葡萄膜炎提供定量信息，包括 ARI 指数、细胞计数和 CCT。SD-OCT 是评估犬前葡萄膜炎的裂隙灯生物显微镜的辅助手段。
