Donovan Taryn A, Garner Michael M, Phalen David, Reavill Drury, Monette Sebastien, Le Roux Alexandre B, Hanson Melissa, Chen Sue, Brown Cyndi, Echeverri Catalina, Quesenberry Katherine
Animal Medical Center, New York, NY, USA.
Northwest ZooPath, Monroe, WA, USA.
Vet Pathol. 2022 Jan;59(1):143-151. doi: 10.1177/03009858211045931. Epub 2021 Nov 18.
Xanthogranulomatosis is an inflammatory lesion characterized by lipid-containing macrophages, extracellular lipid, hemorrhage, and necrosis. We describe disseminated intracoelomic xanthogranulomatosis in 5 eclectus parrots () and 2 budgerigars (). Postmortem, clinicopathologic, and historical case material was reviewed. Ages ranged from 3 to 24 years; there were 5 males and 2 females. Table food was included in the diet of 3/5 cases, and animal products were included in 2/3 cases. Common clinicopathologic abnormalities included leukocytosis (4/5 cases) and elevated concentrations of bile acids (3/4 cases) and cholesterol within 6 months prior to death (2/4 cases). At postmortem examination, all 7 birds had grossly visible, irregular, soft, tan to yellow, amorphous plaques distributed on the surfaces of the viscera and body wall. Histologic evaluation and oil red O stain revealed xanthogranulomatous inflammation with phagocytized and extracellular lipid, necrosis, cholesterol clefts, fibrosis, and mineralization. Infectious agents were not identified with special stains in all cases. Concurrent hepatobiliary disease was present in 6/7 cases, and 6/7 had lipid accumulation within the parenchyma of various visceral organs. Five cases had atherosclerosis of great vessels. We describe a unique form of disseminated coelomic xanthogranulomatosis in 2 psittacine species. This condition should be recognized as a differential diagnosis in cases of disseminated coelomic mass formation and coelomic distension in psittacine birds, particularly in eclectus parrots and budgerigars.
黄色肉芽肿病是一种以含脂质巨噬细胞、细胞外脂质、出血和坏死为特征的炎性病变。我们描述了5只折衷鹦鹉和2只虎皮鹦鹉体内播散性体腔黄色肉芽肿病的情况。对尸检、临床病理和病史病例资料进行了回顾。年龄范围为3至24岁；其中5只为雄性，2只为雌性。5例中有3例的饮食中包含表食，3例中有2例包含动物产品。常见的临床病理异常包括白细胞增多（4/5例）、胆汁酸浓度升高（3/4例）以及死亡前6个月内胆固醇升高（2/4例）。尸检时，所有7只鸟的内脏和体壁表面均可见明显的、不规则的、柔软的、棕褐色至黄色的无定形斑块。组织学评估和油红O染色显示黄色肉芽肿性炎症，伴有吞噬的和细胞外脂质、坏死、胆固醇裂隙、纤维化和矿化。所有病例经特殊染色均未发现感染因子。6/7例存在并发肝胆疾病，6/7例在各种内脏器官实质内有脂质蓄积。5例有大血管动脉粥样硬化。我们描述了2种鹦鹉体内一种独特形式的播散性体腔黄色肉芽肿病。在鹦鹉出现播散性体腔肿物形成和体腔扩张的病例中，尤其是折衷鹦鹉和虎皮鹦鹉，这种情况应被视为鉴别诊断之一。
