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成功应用新辅助化疗并手术切除一只在所罗门岛吸蜜鹦鹉体内的非转移性睾丸圆形细胞肿瘤()。

Successful Neoadjuvant Chemotherapy and Surgical Removal of a Nonmetastatic Testicular Round Cell Tumor in a Solomon Island Eclectus Parrot ().

机构信息

Medical Center for Birds, Oakley, CA 94561, USA,

Medical Center for Birds, Oakley, CA 94561, USA.

出版信息

J Avian Med Surg. 2024 Oct;38(3):153-161. doi: 10.1647/AVIANMS-D-24-00001.

DOI:10.1647/AVIANMS-D-24-00001
PMID:39405214
Abstract

An intracoelomic mass was palpated on an annual exam of a 24-year-old male Solomon Island eclectus parrot (). The initial diagnostic workup included a complete blood count, plasma biochemistry panel, and coelomic ultrasound. Computed tomography was highly suggestive of a testicular mass. Tamoxifen and the gonadotropin-releasing hormone agonists leuprolide and deslorelin were administered as neoadjunctive endocrine therapies. Biopsy and histologic examination confirmed a testicular mass consistent with a round cell tumor. Four doses of carboplatin 15 mg/kg IV were administered as neoadjunctive chemotherapy, and testicular size decreased by approximately 95%. The remaining gross tumor was removed via orchidectomy with clean but narrow margins. Seven months following surgery, a contrast CT scan did not show any evidence of recurrence of or metastasis from the original mass. This is the first report of successful treatment of a testicular tumor in a psittacine with neoadjuvant chemotherapy and orchidectomy.

摘要

在对一只 24 岁的所罗门岛吸蜜鹦鹉进行年度检查时,触诊到一个腹腔内肿块。初步诊断包括全血细胞计数、血浆生化小组和腹腔超声检查。计算机断层扫描高度提示为睾丸肿块。他莫昔芬和促性腺激素释放激素激动剂亮丙瑞林和地洛瑞林被用作新辅助内分泌治疗。活检和组织学检查证实为睾丸肿块,符合圆形细胞瘤。给予 4 剂卡铂 15mg/kg IV 作为新辅助化疗,睾丸大小缩小约 95%。剩余的大体肿瘤通过睾丸切除术切除,切缘干净但狭窄。手术后 7 个月,对比 CT 扫描未显示原始肿块有复发或转移的迹象。这是首例通过新辅助化疗和睾丸切除术成功治疗鹦鹉睾丸肿瘤的报告。

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