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Dent Clin North Am. 2022 Jan;66(1):39-51. doi: 10.1016/j.cden.2021.08.003. Epub 2021 Oct 9.
Technological innovations in cellular and molecular aspects of tissue engineering --scaffolds, stem cells and 3D printed tissues --have been dramatically increased in the last decade. However, regenerative treatment still has challenges in translation to clinic. This is partly due to failure of addressing an essential element of wound healing, inflammation. It is now well-recognized that inflammation is an active process. This paradigm shift opened up a new avenue of therapeutic approaches called "host-modulation." Host-modulation therapies capable of modulating inflammatory response at multiple levels and mimicking the natural sequence of wound healing offer a new direction and promising clinical translation.
在过去的十年中，细胞和分子组织工程方面的技术创新——支架、干细胞和 3D 打印组织——有了显著的增长。然而，再生治疗在转化为临床应用方面仍然面临挑战。这在一定程度上是由于未能解决伤口愈合的一个基本要素——炎症。现在人们已经认识到，炎症是一个活跃的过程。这种范式转变开辟了一种新的治疗方法，称为“宿主调节”。能够在多个层面调节炎症反应并模拟伤口愈合自然过程的宿主调节疗法为我们提供了一个新的方向和有前途的临床转化途径。
