针对 c-Met 改善转移性肾细胞癌的免疫检查点抑制。
Targeting c-Met to Improve Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma.
机构信息
Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Eur Urol. 2022 Jan;81(1):1-2. doi: 10.1016/j.eururo.2021.10.025. Epub 2021 Nov 15.
c-Met inhibition has direct antitumor effects on proliferation, angiogenesis, and metastasis, and indirect antitumor effects via prevention of the induction of immunosuppressive mechanisms (PD-L1, TGFβ, IDO1). c-Met inhibition is key to overcome resistance to immune checkpoint inhibition and to maximize the efficacy of immunotherapy.
c-Met 抑制对增殖、血管生成和转移具有直接的抗肿瘤作用，并通过预防诱导免疫抑制机制（PD-L1、TGFβ、IDO1）产生间接的抗肿瘤作用。c-Met 抑制是克服免疫检查点抑制耐药性和最大限度提高免疫治疗效果的关键。
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