Potential anticancer activity of Acetone extracts of , and on HeLa cervical cancer cells.

BACKGROUND

Cervical cancer is common in women in less developed regions of the world. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combinations might result in reduced toxicity and increased efficacy of the treatment regimen.

OBJECTIVES

The anti-HeLa cells activity of the acetone extracts of , T. cilliata and was assessed using different parameters.

METHODS

Secondary metabolite detection and antioxidant activity quantification were determined using the DPPH and ferric iron reducing assays. HeLa cell growth inhibition and mechanistics were assessed by employing MTT and Annexin-V flous assays.

RESULTS

Observations revealed the presence of phenolic, flavonoids, tannins steroids and coumarins in all the plants extracts. High amount of total phenolic and flavonoid content were detected in and extract had the best DPPH scavenging activity and ferric reducing powers.

CONCLUSION

Observable concentration dependent cell proliferation inhibition by test materials was exhibited. The leaf extracts from T. cilliata, and contain compounds of various polarities with free-radical, antioxidant and anti-cancerous activities that may play a beneficial role in treatment.