Irvine C H, Alexander S L
Veterinary Science Department, Lincoln College, Canterbury, New Zealand.
J Reprod Fertil Suppl. 1987;35:19-24.
A direct method for measuring the capacity of the high-affinity binding protein, CBG, based on charcoal adsorption, was validated for use in the horse. Several unique aspects of cortisol binding in the horse were observed: (1) CBG content at birth was the lowest of any species studied, (2) CBG concentration increased with age whereas in other species it decreases, (3) the plasma of the new born foal has a binding protein, not reported for other species, which binds as much cortisol as does CBG. Its capacity and affinity are intermediate between albumin and CBG. It may be involved prenatally in increasing dam to fetus transfer of cortisol, and post-natally in buffering the effects of the huge stress-related peripartum release of cortisol.
一种基于活性炭吸附来测量高亲和力结合蛋白皮质类固醇结合球蛋白（CBG）容量的直接方法，已在马身上得到验证。研究发现马的皮质醇结合存在几个独特之处：（1）出生时的CBG含量是所有研究物种中最低的；（2）CBG浓度随年龄增长而增加，而在其他物种中则下降；（3）新生马驹的血浆中有一种其他物种未报道过的结合蛋白，其结合皮质醇的量与CBG相同。它的容量和亲和力介于白蛋白和CBG之间。它可能在产前参与增加母体向胎儿的皮质醇转运，并在产后缓冲围产期与应激相关的大量皮质醇释放的影响。
