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妊娠期外阴平滑肌肉瘤

Vulvar Leiomyosarcoma in Pregnancy.

作者信息

Aljehani Ala M, Quatei Amani, Qattea Lina, Aljohani Renad M, Alkushi Abdulmohsen

机构信息

Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU.

Obstetrics and Gynecology, King Fahad Medical City, Riyadh, SAU.

出版信息

Cureus. 2021 Oct 14;13(10):e18772. doi: 10.7759/cureus.18772. eCollection 2021 Oct.

DOI:10.7759/cureus.18772
PMID:34796063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8590387/
Abstract

Vulvar leiomyosarcoma is a rare smooth muscle malignant neoplasm but it is the commonest type of vulvar sarcomas. It may mimic benign tumors and misdiagnosis could delay proper management. We report a case of a 38-year-old pregnant woman with leiomyosarcoma of the vulva. The patient presented to her primary general practitioner with a small vulvar mass that she had first noticed one year prior. The tumor was suspected to be benign Bartholin's cyst and treated with antibiotics. The patient declined improvement and had many consultations to different clinics where she had been diagnosed and treated the same. The tumor size started to grow rapidly after she got pregnant, and the patient was referred to our hospital where she underwent tumor resection. Histopathology revealed leiomyosarcoma. The patient had further assessment and close follow-up and has had no recurrence for 12 months. There is little literature available on vulvar leiomyosarcoma, most of which are case reports, and most gynecologic oncologists will go through their whole careers without seeing a single case.

摘要

外阴平滑肌肉瘤是一种罕见的平滑肌恶性肿瘤,但却是最常见的外阴肉瘤类型。它可能会模仿良性肿瘤,误诊可能会延误正确的治疗。我们报告一例38岁的外阴平滑肌肉瘤孕妇病例。患者因一年前首次发现的外阴小肿块就诊于她的初级全科医生。该肿瘤被怀疑是良性巴氏腺囊肿,并接受了抗生素治疗。患者病情未见好转,在不同诊所进行了多次会诊,在那里她得到了相同的诊断和治疗。怀孕后肿瘤大小开始迅速增长,患者被转诊至我院,在我院接受了肿瘤切除术。组织病理学显示为平滑肌肉瘤。患者接受了进一步评估和密切随访,12个月来无复发。关于外阴平滑肌肉瘤的文献很少,其中大部分是病例报告,大多数妇科肿瘤学家在其整个职业生涯中可能都不会见到一例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/18efaf7b9c0e/cureus-0013-00000018772-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/182b77fd4ad6/cureus-0013-00000018772-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/9100df6085c2/cureus-0013-00000018772-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/0e3f662e0fdf/cureus-0013-00000018772-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/5ad13013e0af/cureus-0013-00000018772-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/18efaf7b9c0e/cureus-0013-00000018772-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/182b77fd4ad6/cureus-0013-00000018772-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/9100df6085c2/cureus-0013-00000018772-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/0e3f662e0fdf/cureus-0013-00000018772-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/5ad13013e0af/cureus-0013-00000018772-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47bc/8590387/18efaf7b9c0e/cureus-0013-00000018772-i05.jpg

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Common and uncommon lesions of the vulva and vagina on magnetic resonance imaging: correlations with pathological findings.磁共振成像外阴和阴道常见及罕见病变:与病理结果的相关性
BJR Open. 2023 Jun 28;5(1):20230002. doi: 10.1259/bjro.20230002. eCollection 2023.
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Vulvar Leiomyosarcomas: A Case Series with Clinical Comparison to Uterine Leiomyosarcomas and Review of the Literature.外阴平滑肌肉瘤:与子宫平滑肌肉瘤的临床比较病例系列及文献复习。
Am J Case Rep. 2023 May 27;24:e939402. doi: 10.12659/AJCR.939402.

本文引用的文献

1
Primary vulvar leiomyosarcoma localized in the Bartholin's gland area: A case report and review.原发性外阴平滑肌肉瘤局限于巴氏腺区域:一例报告及文献复习
Mol Clin Oncol. 2021 Apr;14(4):69. doi: 10.3892/mco.2021.2231. Epub 2021 Feb 9.
2
Leiomyosarcoma of the Vulva Mimicking as Chronic Bartholin Cyst: A Case Report.外阴平滑肌肉瘤误诊为慢性巴氏腺囊肿:一例报告
Oman Med J. 2020 Jul 29;35(4):e153. doi: 10.5001/omj.2020.74. eCollection 2020 Jul.
3
Smooth Muscle Tumors of the Female Genital Tract.女性生殖道平滑肌瘤
Surg Pathol Clin. 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004.
4
Criteria for Risk Stratification of Vulvar and Vaginal Smooth Muscle Tumors: An Evaluation of 71 Cases Comparing Proposed Classification Systems.外阴和阴道平滑肌肿瘤的风险分层标准:对71例病例的评估及对提议分类系统的比较
Am J Surg Pathol. 2018 Jan;42(1):84-94. doi: 10.1097/PAS.0000000000000920.
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Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1.外阴肉瘤:组织病理学识别与临床管理简短指南。第1部分。
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Leiomyosarcoma of the vulva.外阴平滑肌肉瘤
Eur J Gynaecol Oncol. 2012;33(3):306-8.
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Leiomyosarcoma of the vagina: a case report and review from the literature.阴道平滑肌肉瘤:病例报告及文献复习。
J Gynecol Oncol. 2008 Dec;19(4):261-4. doi: 10.3802/jgo.2008.19.4.261. Epub 2008 Dec 29.
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Leiomyosarcoma of the vulva.外阴平滑肌肉瘤
J Eur Acad Dermatol Venereol. 2006 Jan;20(1):116-7. doi: 10.1111/j.1468-3083.2006.01341.x.
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Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy.208例子宫平滑肌肉瘤患者的回顾性研究:预后指标、手术治疗及辅助治疗
Gynecol Oncol. 2003 Jun;89(3):460-9. doi: 10.1016/s0090-8258(03)00137-9.
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Leiomyosarcoma of the vulva. A case report.外阴平滑肌肉瘤。病例报告。
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