Centre for Interdisciplinary Research in Rehabilitation, Lethbridge-Layton-Mackay Rehabilitation Centre, and School of Physical and Occupational Therapy, McGill University, Montreal, Canada.
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada.
J Orthop Res. 2022 Aug;40(8):1778-1786. doi: 10.1002/jor.25219. Epub 2021 Nov 18.
The relationship between knee moments and markers of knee osteoarthritis progression has not been examined in different knee osteoarthritis subtypes. The objective was to examine relationships between external knee moments during gait and tibiofemoral cartilage thickness in patients with nontraumatic and posttraumatic knee osteoarthritis. For this cross-sectional study, participants with knee osteoarthritis were classified into two groups: nontraumatic (n = 22; mean age 60 years) and posttraumatic (n = 19; mean age 56 years, history of anterior cruciate ligament rupture). Gait data were collected with a three-dimensional motion capture system sampled at 100 Hz and force plates sampled at 2000 Hz. External knee moments were calculated using inverse dynamics. Cartilage thickness was determined with magnetic resonance imaging (T1-weighted, 3D sagittal gradient-echo sequence). Linear regression analyses examined relationships between cartilage thickness with knee moments, group, and their interaction. A higher knee adduction moment impulse was negatively associated with medial to lateral cartilage thickness ratio (B = -1.97). This relationship differed between participants in the nontraumatic osteoarthritis group (r = -0.56) and posttraumatic osteoarthritis group (r = -0.30). A higher late stance knee extension moment was associated with greater medial femoral condyle cartilage thickness (B = -0.86) and medial to lateral cartilage thickness (B = -0.73). These relationships also differed between participants in the nontraumatic osteoarthritis group (r = -0.61 and r = -0.51, respectively) and posttraumatic osteoarthritis group (r = 0.10 and r = 0.25, respectively). Clinical Significance: The relationship between knee moments with tibiofemoral cartilage thickness differs between patients with nontraumatic and posttraumatic knee osteoarthritis. The potential influence of mechanical knee loading on articular cartilage may also differ between these subtypes.
膝关节力矩与膝关节骨关节炎进展标志物之间的关系在不同膝关节骨关节炎亚型中尚未得到研究。本研究旨在探讨非创伤性和创伤后膝关节骨关节炎患者在步态时膝关节外力矩与胫股关节软骨厚度之间的关系。在这项横断面研究中，将膝关节骨关节炎患者分为两组：非创伤性（n=22；平均年龄 60 岁）和创伤后（n=19；平均年龄 56 岁，前交叉韧带断裂史）。使用三维运动捕捉系统以 100Hz 采样和力板以 2000Hz 采样收集步态数据。使用逆动力学计算膝关节外力矩。使用磁共振成像（T1 加权，3D 矢状梯度回波序列）确定软骨厚度。线性回归分析检查了软骨厚度与膝关节力矩、组及其相互作用之间的关系。膝关节内收力矩冲量越大，内侧至外侧软骨厚度比越低（B=-1.97）。这种关系在非创伤性骨关节炎组（r=-0.56）和创伤后骨关节炎组（r=-0.30）参与者之间存在差异。站立后期膝关节伸展力矩越大，股骨内侧髁软骨厚度越大（B=-0.86），内侧至外侧软骨厚度比越大（B=-0.73）。这些关系在非创伤性骨关节炎组（r=-0.61 和 r=-0.51）和创伤后骨关节炎组（r=0.10 和 r=0.25）参与者之间也存在差异。临床意义：膝关节力矩与胫股关节软骨厚度之间的关系在非创伤性和创伤后膝关节骨关节炎患者中存在差异。机械性膝关节负荷对关节软骨的潜在影响也可能在这些亚型之间存在差异。
Zotero 插件