Molecular Dermatology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Dermatol Ther. 2022 Jan;35(1):e15212. doi: 10.1111/dth.15212. Epub 2021 Nov 30.
Striae distensae (SD) are common skin conditions that have posed a significant challenge regarding their assessment and treatment. The present study aimed to evaluate the efficacy of microneedling in comparison to fractional CO laser therapy. Similar striae were selected and photographed. Each side was randomly assigned to be treated with CO fractional laser or microneedling four times at monthly intervals and followed up for 10 months. Outcome measures including the length and width of the largest striae, dermatologist assessed improvement, patients' satisfaction, and visual analog scale (VAS) were assessed. Wilcoxon signed-rank test and Mann-Whitney U test were used to assess the efficacy of treatments. Forty patients with a mean age of 28.1 years were included. The median cross-section of the largest striae decreased significantly in both groups (P-value <0.001), without statistically significant differences between the two groups before and 6 months after treatment. VAS also improved significantly in both groups, and there were no statistically significant differences between the two treatments in all visits. No clinically significant adverse effects were observed. Fractional CO laser and microneedling are both efficient treatments to resolve SD. A new light should be shed on the microneedling modality as it is more economical than the other treatment options.
妊娠纹是一种常见的皮肤问题，其评估和治疗一直是一个难题。本研究旨在比较微针和分 子 CO2 激光治疗妊娠纹的疗效。选择相似的妊娠纹并拍照。每侧随机分配接受 CO2 分 子激光或微针治疗，每 4 周 1 次，共 4 次，随访 10 个月。评估指标包括最大妊娠纹的长度和宽度、皮肤科医生评估的改善情况、患者满意度和视觉模拟评分（VAS）。Wilcoxon 符号秩检验和 Mann-Whitney U 检验用于评估治疗效果。共纳入 40 例患者，平均年龄 28.1 岁。两组最大妊娠纹的横截面均显著减小（P 值均<0.001），治疗前和治疗 6 个月后两组间无统计学差异。两组的 VAS 均显著改善，各次随访中两种治疗方法之间无统计学差异。未观察到明显的不良反应。分 子 CO2 激光和微针均是治疗妊娠纹的有效方法。微针治疗因其经济实惠，应引起更多关注。
